Anti-inflammatory results of moxifloxacin on IL8IL-1beta and TNF-alpha secretion and NF kappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus
OBJECTIVE
We now have beforehand proven that moxifloxacin conferred protecting anti-inflammatory results in opposition to Candida pneumonia in immunosuppressed mice. Additional in vitro research confirmed anti-inflammatory results of moxifloxacin in LPS and cytokine-stimulated monocytic and epithelial cells. Within the current examine, concentrating on a more difficult pathogen of immunosuppressed hosts, we studied the impact of moxifloxacin on cytokine secretion and sign transduction mechanisms in monocytic cells stimulated with Aspergillus fumigatus.
METHODS
Human peripheral blood monocytes (PBMCs) and a human monocytic cell line (THP-1) had been incubated with 1.5×10(6)/mL conidia of a scientific isolate of A. fumigatus. Cytokine secretion and activation of NFkappaB and the MAP-kinases ERK1/2 and p38 had been measured with and with out the addition of moxifloxacin (5-20 mg/L).
Human Interleukin-8 (IL-8) Antibody
RESULTS
Stimulation of PBMCs and THP-1 cells with A. fumigatus elevated IL-8, IL-1beta and TNF-alpha secretion (4.1-, 8.3- and 7-fold, and 5.4-, 3.7- and 17.8-fold, respectively). Addition of moxifloxacin (5-20 mg/L) inhibited cytokine secretion as much as 45.7+/-5%, 72+/-13% and 73+/-10% in PBMCs and as much as 35.6+/-0.5%, 30+/-2.4% and 19+/-4% in THP-1 cells (P<0.05). Sign transduction research confirmed that incubation of THP-1 cells with A. fumigatus elevated ERK1/2 and p38 phosphorylation and p65-NFkappaB protein expression by 1.6-, 1.3- and 1.8-fold, respectively. Addition of moxifloxacin inhibited ERK1/2, p38 and p65-NFkappaB by as much as 69+/-14%, 58+/-3% and 75+/-15%, respectively.
human anti-human IL-8 mAb (A5) |
E4A09D07-A5A |
EnoGene |
50ug |
EUR 255 |
Description: Available in various conjugation types. |
human anti-human IL-8 mAb (6G) |
E4A09D07-B5G |
EnoGene |
50ug |
EUR 255 |
Description: Available in various conjugation types. |
human anti-human IL-8 mAb (AB) |
E4A09D07-C8A |
EnoGene |
50ug |
EUR 255 |
Description: Available in various conjugation types. |
human anti-human IL-8 mAb(N2) |
E4A09D07-N2 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-8 mAb(N8) |
E4A09D07-N8 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-8 mAb (1H) Humanized Antibody |
MBS8574794-01mg |
MyBiosource |
0.1mg |
EUR 505 |
human anti-human IL-8 mAb (1H) Humanized Antibody |
MBS8574794-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2015 |
human anti-human IL-8 mAb (2H) Humanized Antibody |
MBS8574795-01mg |
MyBiosource |
0.1mg |
EUR 505 |
human anti-human IL-8 mAb (2H) Humanized Antibody |
MBS8574795-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2015 |
Human Interleukin-8 (IL-8) Antibody |
13102-05011 |
AssayPro |
150 ug |
EUR 175 |
Human IL-8 |
90258-A |
BPS Bioscience |
5 µg |
EUR 130 |
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli. |
Human IL-8 |
90258-B |
BPS Bioscience |
25 µg |
EUR 205 |
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli. |
human-anti-human-IL-8-mAb(1H) |
E409C16-hA100 |
EnoGene |
Inflammation-Storm-Antibodies |
EUR 276.5 |
Description: Inflammation Storm Antibodies |
human-anti-human-IL-8-mAb(2H) |
E409C16-hB100 |
EnoGene |
Inflammation-Storm-Antibodies |
EUR 276.5 |
Description: Inflammation Storm Antibodies |
Anti-Human IL-8 Antibody |
101-M08 |
ReliaTech |
500 µg |
EUR 246.75 |
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10. |
Anti-Human IL-8 Antibody |
102-P38 |
ReliaTech |
100 µg |
EUR 245.7 |
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10. |
mAb anti-Human IL-8 |
MBS592019-01mg |
MyBiosource |
0.1mg |
EUR 365 |
mAb anti-Human IL-8 |
MBS592019-05mg |
MyBiosource |
0.5mg |
EUR 530 |
mAb anti-Human IL-8 |
MBS592019-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2140 |
mAb anti-Human IL-8 |
MBS592095-01mg |
MyBiosource |
0.1mg |
EUR 365 |
mAb anti-Human IL-8 |
MBS592095-05mg |
MyBiosource |
0.5mg |
EUR 530 |
mAb anti-Human IL-8 |
MBS592095-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2140 |
mAb anti-Human IL-8 |
MBS592159-01mg |
MyBiosource |
0.1mg |
EUR 365 |
mAb anti-Human IL-8 |
MBS592159-05mg |
MyBiosource |
0.5mg |
EUR 545 |
mAb anti-Human IL-8 |
MBS592159-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2205 |
mAb anti-Human IL-8 |
MBS592219-01mg |
MyBiosource |
0.1mg |
EUR 365 |
mAb anti-Human IL-8 |
MBS592219-05mg |
MyBiosource |
0.5mg |
EUR 545 |
mAb anti-Human IL-8 |
MBS592219-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2205 |
mAb anti-Human IL-8 |
MBS592256-01mg |
MyBiosource |
0.1mg |
EUR 365 |
mAb anti-Human IL-8 |
MBS592256-05mg |
MyBiosource |
0.5mg |
EUR 530 |
mAb anti-Human IL-8 |
MBS592256-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2140 |
Mouse Anti-Human IL-8 |
MBS690051-05mg |
MyBiosource |
0.5mg |
EUR 525 |
Mouse Anti-Human IL-8 |
MBS690051-5x05mg |
MyBiosource |
5x0.5mg |
EUR 2080 |
Anti-Human IL-8 (CXCL8) |
MBS550689-01mg |
MyBiosource |
0.1mg |
EUR 260 |
Anti-Human IL-8 (CXCL8) |
MBS550689-02mg |
MyBiosource |
0.2mg |
EUR 335 |
Anti-CXCL8 / IL-8 Reference Antibody (Genentech anti-IL-8) |
E24CHA784 |
EnoGene |
100 μg |
EUR 225 |
Description: Available in various conjugation types. |
Human IL-8 (77aa) |
MBS691916-0005mg |
MyBiosource |
0.005mg |
EUR 300 |
Human IL-8 (77aa) |
MBS691916-0025mg |
MyBiosource |
0.025mg |
EUR 450 |
Human IL-8 (77aa) |
MBS691916-5x0025mg |
MyBiosource |
5x0.025mg |
EUR 1725 |
IL-8 (72aa), Human |
MBS8575167-0005mg |
MyBiosource |
0.005mg |
EUR 245 |
IL-8 (72aa), Human |
MBS8575167-5x0005mg |
MyBiosource |
5x0.005mg |
EUR 940 |
Human CXCL8 (IL-8) |
MBS444011-0005mg |
MyBiosource |
0.005mg |
EUR 150 |
Human CXCL8 (IL-8) |
MBS444011-002mg |
MyBiosource |
0.02mg |
EUR 210 |
Human CXCL8 (IL-8) |
MBS444011-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Human CXCL8 (IL-8) |
MBS444011-01mg |
MyBiosource |
0.1mg |
EUR 480 |
Human CXCL8 (IL-8) |
MBS444011-1mg |
MyBiosource |
1mg |
EUR 1910 |
Human CXCL8 (IL-8) |
MBS444019-0002mg |
MyBiosource |
0.002mg |
EUR 195 |
Human CXCL8 (IL-8) |
MBS444019-001mg |
MyBiosource |
0.01mg |
EUR 530 |
Human CXCL8 (IL-8) |
MBS444019-005mg |
MyBiosource |
0.05mg |
EUR 1760 |
Human CXCL8 (IL-8) |
MBS444019-01mg |
MyBiosource |
0.1mg |
EUR 2890 |
Human IL-8 Protein |
abx060803-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 Protein |
abx060804-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 protein |
PRP1022-100ug |
Abbkine |
100 μg |
EUR 449 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-10ug |
Abbkine |
10 μg |
EUR 59 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-1mg |
Abbkine |
1 mg |
EUR 2609 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-50ug |
Abbkine |
50 μg |
EUR 249 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 Protein |
E2RB20061PT |
EnoGene |
100ul |
EUR 485 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Human IL-8 protein |
MBS9719016-001mg |
MyBiosource |
0.01mg |
EUR 115 |
Human IL-8 protein |
MBS9719016-005mg |
MyBiosource |
0.05mg |
EUR 225 |
Human IL-8 protein |
MBS9719016-01mg |
MyBiosource |
0.1mg |
EUR 345 |
Human IL-8 protein |
MBS9719016-1mg |
MyBiosource |
1mg |
EUR 1745 |
Human IL-8 protein |
MBS9719016-5x1mg |
MyBiosource |
5x1mg |
EUR 7815 |
Human Interleukin 8(IL-8)ELISA Kit
CONCLUSIONS
Our outcomes point out that moxifloxacin acts as an anti-inflammatory agent in monocytic cells stimulated with A. fumigatus conidia. Whether or not these results could also be protecting as within the Candida pneumonia mannequin is unknown and deserves in vivo research in fashions of pulmonary aspergillosis.
Human pores and skin mast cells quickly launch preformed and newly generated TNF-alpha and IL-Eight following stimulation with anti-IgE and different secretagogues
- A number of teams have beforehand reported that rodent or human leukemic mast cells produce inflammatory cytokines akin to TNF-alpha and IL-Eight in addition to the pro-allergic cytokines IL-4, IL-5 and IL-13. Comparatively little is understood, nonetheless, relating to the flexibility of regular human pores and skin mast cells to secrete these components following both IgE-dependent or IgE-independent modes of activation.
CXCL8 Antibody, Biotin conjugated | CXCL8 Antibody, FITC conjugated
- We subsequently investigated whether or not regular human pores and skin mast cells produce these cytokines following stimulation by quite a lot of secretagogues. Enriched remoted pores and skin mast cells launched each TNF-alpha and IL-Eight following activation with both anti-IgE, SCF, substance P, compound 48/80 or A23187. This launch was dose- and time-dependent, with maximal ranges being reached inside Four h of stimulation involving, partly, the secretion of preformed shops of each cytokines.
Recombinant Human CXCL8 |
50190P-100 |
Genovis AB |
100ug |
EUR 551 |
Recombinant Human CXCL8 |
50190P-1000 |
Genovis AB |
1000ug |
EUR 2503 |
Recombinant Human CXCL8 |
50190P-20 |
Genovis AB |
20ug |
EUR 159 |
Recombinant Human CXCL8 |
50190P-5 |
Genovis AB |
5ug |
EUR 75 |
Recombinant Human CXCL8 |
50190P-50 |
Genovis AB |
50ug |
EUR 350 |
Anti-Human IL-8 (CXCL8) |
MBS550689-01mg |
MyBiosource |
0.1mg |
EUR 260 |
Anti-Human IL-8 (CXCL8) |
MBS550689-02mg |
MyBiosource |
0.2mg |
EUR 335 |
Anti-Human IL8/CXCL8 Antibody |
MBS1569809-01mg |
MyBiosource |
0.1mg |
EUR 375 |
Anti-Human IL8/CXCL8 Antibody |
MBS1569809-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1390 |
Human CXCL8 (IL-8) |
MBS444011-0005mg |
MyBiosource |
0.005mg |
EUR 150 |
Human CXCL8 (IL-8) |
MBS444011-002mg |
MyBiosource |
0.02mg |
EUR 210 |
Human CXCL8 (IL-8) |
MBS444011-005mg |
MyBiosource |
0.05mg |
EUR 325 |
Human CXCL8 (IL-8) |
MBS444011-01mg |
MyBiosource |
0.1mg |
EUR 480 |
Human CXCL8 (IL-8) |
MBS444011-1mg |
MyBiosource |
1mg |
EUR 1910 |
Human CXCL8 (IL-8) |
MBS444019-0002mg |
MyBiosource |
0.002mg |
EUR 195 |
Human CXCL8 (IL-8) |
MBS444019-001mg |
MyBiosource |
0.01mg |
EUR 530 |
Human CXCL8 (IL-8) |
MBS444019-005mg |
MyBiosource |
0.05mg |
EUR 1760 |
Human CXCL8 (IL-8) |
MBS444019-01mg |
MyBiosource |
0.1mg |
EUR 2890 |
Human CXCL8 ELISA Kit |
STJ150098 |
St John's Laboratory |
1 kit |
EUR 494.4 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of IL-8 in human serum, plasma and other biological fluids |
Human CXCL8 Protein Lysate |
MBS8410155-002mg |
MyBiosource |
0.02mg |
EUR 365 |
Human CXCL8 Protein Lysate |
MBS8410155-5x002mg |
MyBiosource |
5x0.02mg |
EUR 1410 |
anti- CXCL8/IL8 antibody |
FNab09864 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against CXCL8/IL8 |
Human Interleukin-8 (CXCL8) |
1-CSB-YP011671HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in Yeast |
Human Interleukin-8 (CXCL8) |
1-CSB-EP011671HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in E.coli |
Anti-IL8/CXCL8 Antibody |
PB9621 |
BosterBio |
100ug/vial |
EUR 400.8 |
Recombinant Human CXCL8, biotinylated |
50190PB |
Genovis AB |
10ug |
EUR 624 |
Recombinant Human CXCL8, biotinylated |
50190PB-10 |
Genovis AB |
10ug |
EUR 624 |
Recombinant Human CXCL8, biotinylated |
50190PB-100 |
Genovis AB |
100ug |
EUR 3852 |
Recombinant Human CXCL8, biotinylated |
50190PB-2 |
Genovis AB |
2ug |
EUR 153 |
Recombinant Human CXCL8, biotinylated |
50190PB-50 |
Genovis AB |
50ug |
EUR 2302 |
Human CXCL8 Protein, Fc Tag |
E40KMPH5724 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1200 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1201 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1203 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1204 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1205 |
EnoGene |
20ug |
EUR 495 |
InVivoMAb Anti-Human IL8/CXCL8 (Iv0023) |
MBS1570048-01mg |
MyBiosource |
0.1mg |
EUR 405 |
InVivoMAb Anti-Human IL8/CXCL8 (Iv0023) |
MBS1570048-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1520 |
Human CXCL8 Protein, His Tag |
E40KMPH1202 |
EnoGene |
20ug |
EUR 495 |
Human IL-8 (72aa) (CXCL8) |
MBS692017-0005mg |
MyBiosource |
0.005mg |
EUR 300 |
Human IL-8 (72aa) (CXCL8) |
MBS692017-0025mg |
MyBiosource |
0.025mg |
EUR 450 |
Human IL-8 (72aa) (CXCL8) |
MBS692017-5x0025mg |
MyBiosource |
5x0.025mg |
EUR 1725 |
Human CXCL8 Protein Lysate 20ug |
IHUCXCL8PLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human CXCL8 Protein Lysate 20ug |
Recombinant Human IL-8/CXCL8 |
PH2009-.01 |
ApexBio |
10ug |
EUR 208 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human IL-8/CXCL8 |
PH2009-.1 |
ApexBio |
10X10ug |
EUR 592 |
Description: Peptides & Proteins|Recombinant Proteins |
Human IL-8/CXCL8 Antibody Pair Set |
ABPR-ZB076 |
Creative Diagnostics |
5 plates, 15 plates |
Ask for price |
Description: Quantitative determination of Human IL-8/CXCL8 |
CXCL8 ELISA Kit (Human) (OKAN04343) |
OKAN04343 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04344) |
OKAN04344 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04345) |
OKAN04345 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL |
Human Interleukin 8 (CXCL8) Protein |
abx694105-10nmol |
Abbexa |
10 nmol |
EUR 400 |
Human Interleukin 8 (CXCL8) Protein |
abx694105-5nmol |
Abbexa |
5 nmol |
EUR 300 |
Human CXCL8 Recombinant Protein Lyophilized |
IHUCXCL8RLY5UG |
Innovative research |
each |
EUR 341 |
|
Description: Human CXCL8 Recombinant Protein Lyophilized |
Human CXCL8 Recombinant Protein Lyophilized |
MBS8431811-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
Mouse Monoclonal anti-human CXCL8 (IL-8) |
hAP-0219 |
Angio Proteomie |
100ug |
EUR 250 |
Sheep Polyclonal anti-human CXCL8 (IL-8) |
hAP-5118 |
Angio Proteomie |
50ug |
EUR 400 |
Human IL-8/CXCL8 ELISA Kit |
RK00011 |
Abclonal |
96 Tests |
EUR 280 |
Human IL-8/CXCL8 ELISA kit |
MBS7275583-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 6265 |
Human IL-8/CXCL8 ELISA kit |
MBS7275583-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 485 |
Human IL-8/CXCL8 ELISA kit |
MBS7275583-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 3175 |
Human IL-8/CXCL8 ELISA kit |
MBS7275583-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 690 |
Human IL-8/CXCL8 ELISA Kit |
MBS9135731-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2615 |
Human IL-8/CXCL8 ELISA Kit |
MBS9135731-96Tests |
MyBiosource |
96Tests |
EUR 570 |
Recombinant Human Interleukin-8(CXCL8) |
AP77798 |
SAB |
each |
Ask for price |
|
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115059-001mg |
MyBiosource |
0.01mg |
EUR 250 |
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115059-005mg |
MyBiosource |
0.05mg |
EUR 510 |
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115059-5x005mg |
MyBiosource |
5x0.05mg |
EUR 2145 |
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115061-001mg |
MyBiosource |
0.01mg |
EUR 240 |
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115061-005mg |
MyBiosource |
0.05mg |
EUR 505 |
Recombinant Human Interleukin-8 (CXCL8) |
MBS7115061-5x005mg |
MyBiosource |
5x0.05mg |
EUR 2120 |
Human CXCL8/ Interleukin-8 ELISA Kit |
E0623Hu |
Sunlong |
1 Kit |
EUR 515 |
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Description: IL8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,Monocyte-derived neutrophil chemotactic factor,Monocyte-derived neutrophil-activating peptide,Neutrophil-activating protein 1,Protein 3-10C,T-cell chemotactic factor,GCP-1,MDNCF,MONAP,NAP-1 |
Human CXCL8 / Interleukin-8 ELISA Kit |
E0080h |
EIAab |
96T |
EUR 536 |
Recombinant Human CXCL8/IL-8 Protein |
RP00482 |
Abclonal |
10μg |
EUR 170.04 |
Recombinant Human CXCL8/IL-8 Protein |
RP00483 |
Abclonal |
10μg |
EUR 159.41 |
IL-8/CXCL8 (CHO-expressed), Human |
HY-P7379 |
MedChemExpress |
50ug |
EUR 596.4 |
CXCL8 Antibody |
E912452 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
CXCL8 Antibody |
E91289 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
CXCL8 antibody |
70R-21501 |
Fitzgerald |
50 ul |
EUR 289 |
|
Description: Rabbit polyclonal CXCL8 antibody |
CXCL8 Antibody |
1-CSB-PA004977 |
Cusabio |
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Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA011671GA01HU |
Cusabio |
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Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
CXCL8 Antibody |
1-CSB-PA011671YA01DO |
Cusabio |
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Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
1-CSB-PA009564 |
Cusabio |
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Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
CXCL8 Antibody |
1-CSB-PA003036 |
Cusabio |
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Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
- In accordance with this, utilizing lysates of extremely purified (>90%) pores and skin mast cells, we might display that each TNF-alpha and IL-Eight mRNA and protein had been current in each unstimulated in addition to stimulated mast cells. In stark distinction to those outcomes, no important ranges of both IL-4, IL-5 or IL-13 had been detected, whatever the secretagogue used or the interval of stimulation.
- These outcomes present that human pores and skin mast cells are able to quickly secreting pro-inflammatory cytokines like TNF-alpha and IL-Eight following IgE-dependent activation and stimulation by the neuropeptide substance P, SCF and the essential polypeptide analogue compound 48/80. In distinction to different forms of human mast cells nonetheless, human pores and skin mast cells had been incapable of secreting IL-4, IL-5 or IL-13 in these settings.