Anti-inflammatory results of moxifloxacin on IL8IL-1beta and TNF-alpha secretion and NF kappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus
OBJECTIVE
We now have beforehand proven that moxifloxacin conferred protecting anti-inflammatory results in opposition to Candida pneumonia in immunosuppressed mice. Additional in vitro research confirmed anti-inflammatory results of moxifloxacin in LPS and cytokine-stimulated monocytic and epithelial cells. Within the current examine, concentrating on a more difficult pathogen of immunosuppressed hosts, we studied the impact of moxifloxacin on cytokine secretion and sign transduction mechanisms in monocytic cells stimulated with Aspergillus fumigatus.
METHODS
Human peripheral blood monocytes (PBMCs) and a human monocytic cell line (THP-1) had been incubated with 1.5×10(6)/mL conidia of a scientific isolate of A. fumigatus. Cytokine secretion and activation of NFkappaB and the MAP-kinases ERK1/2 and p38 had been measured with and with out the addition of moxifloxacin (5-20 mg/L).
Human Interleukin-8 (IL-8) Antibody
RESULTS
Stimulation of PBMCs and THP-1 cells with A. fumigatus elevated IL-8, IL-1beta and TNF-alpha secretion (4.1-, 8.3- and 7-fold, and 5.4-, 3.7- and 17.8-fold, respectively). Addition of moxifloxacin (5-20 mg/L) inhibited cytokine secretion as much as 45.7+/-5%, 72+/-13% and 73+/-10% in PBMCs and as much as 35.6+/-0.5%, 30+/-2.4% and 19+/-4% in THP-1 cells (P<0.05). Sign transduction research confirmed that incubation of THP-1 cells with A. fumigatus elevated ERK1/2 and p38 phosphorylation and p65-NFkappaB protein expression by 1.6-, 1.3- and 1.8-fold, respectively. Addition of moxifloxacin inhibited ERK1/2, p38 and p65-NFkappaB by as much as 69+/-14%, 58+/-3% and 75+/-15%, respectively.
human anti-human IL-8 mAb(N8) |
E4A09D07-N8 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Anti-Human IL-8 Antibody |
101-M08 |
ReliaTech |
500 µg |
EUR 246.75 |
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10. |
Anti-Human IL-8 Antibody |
102-P38 |
ReliaTech |
100 µg |
EUR 245.7 |
Description: Il-8 or CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10. |
Human Interleukin-8 (IL-8) Antibody |
13102-05011 |
AssayPro |
150 ug |
EUR 175 |
Human IL-8 |
90258-A |
BPS Bioscience |
5 µg |
EUR 130 |
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli. |
Human IL-8 |
90258-B |
BPS Bioscience |
25 µg |
EUR 205 |
Description: Recombinant human Interleukin-8 is a disulfide-linked monomer protein consisting of 78 amino acid residues, migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-8 mature chain was expressed in E. coli. |
Anti-CXCL8 / IL-8 Reference Antibody (Genentech anti-IL-8) |
E24CHA784 |
EnoGene |
100 μg |
EUR 225 |
Description: Available in various conjugation types. |
human-anti-human-IL-8-mAb(1H) |
E409C16-hA100 |
EnoGene |
Inflammation-Storm-Antibodies |
EUR 276.5 |
Description: Inflammation Storm Antibodies |
human-anti-human-IL-8-mAb(2H) |
E409C16-hB100 |
EnoGene |
Inflammation-Storm-Antibodies |
EUR 276.5 |
Description: Inflammation Storm Antibodies |
Anti-IL-8 Antibody |
A00423 |
BosterBio |
1 mL |
EUR 1444.8 |
Description: Rabbit Polyclonal IL-8 Antibody. Validated in IP, WB and tested in Human. |
Anti-IL-8 Antibody |
A2062-100 |
Biovision |
100 µg |
EUR 472.8 |
Anti-IL-8 Antibody |
ER1706-67 |
HUABIO |
100ul |
EUR 189 |
|
Description: Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells, also known as recent thymic emigrants. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers. |
Anti-IL-8 Antibody |
ER1901-61 |
HUABIO |
100ul |
EUR 189 |
|
Description: IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst.IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers. |
Anti-IL-8 Antibody |
R1511-15 |
HUABIO |
100ul |
EUR 189 |
|
Anti-IL-8 Antibody |
Y123169 |
ABM |
100 µl |
EUR 320 |
Anti-IL-8 antibody |
STJ98175 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ97710 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ97717 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ97720 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
anti-IL-8 (3E4D8) |
LF-MA30011 |
Abfrontier |
100 ul |
EUR 448.8 |
Description: Mouse Monoclonal to IL-8 |
Anti- Interleukin-8 (IL-8) Antibody |
GWB-7ACF57 |
GenWay Biotech |
0.05 mg |
Ask for price |
mAb mouse anti-human IL-8 |
CT264 |
U-CyTech |
0.5 mg |
EUR 312 |
mouse anti-human IL-8 mAb |
E409C16-m100 |
EnoGene |
100μL |
EUR 395 |
Description: Available in various conjugation types. |
Recombinant Human IL-8 (72a.a.)(rHu IL-8/CXCL8) |
701081 |
SAB |
25ul |
EUR 235 |
|
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg. |
Recombinant Human IL-8 (77a.a.)(rHu IL-8/CXCL8) |
701082 |
SAB |
25ul |
EUR 235 |
|
Description: Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg. |
Human IL-8 Protein |
abx060803-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 Protein |
abx060804-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 protein |
PRP1022-100ug |
Abbkine |
100 μg |
EUR 449 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-10ug |
Abbkine |
10 μg |
EUR 59 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-1mg |
Abbkine |
1 mg |
EUR 2609 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 protein |
PRP1022-50ug |
Abbkine |
50 μg |
EUR 249 |
Description: Human IL-8 protein, expressed in E. coli |
Human IL-8 Protein |
E2RB20061PT |
EnoGene |
100ul |
EUR 485 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Interleukin-8 (IL-8) (72a.a) Human |
GWB-3997EC |
GenWay Biotech |
0.025 mg |
Ask for price |
|
Recombinant Human IL-8 |
P0180 |
FN Test |
100ug |
EUR 626.83 |
|
Description: Recombinant Human protein for IL-8 |
Recombinant Human IL-8 |
SJB05-01 |
Amyotop |
25µg/vial |
EUR 342 |
Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate) |
13102-05021 |
AssayPro |
150 ug |
EUR 229 |
Rabbit anti-IL-8 Antibody |
DL90596A-100ul |
DL Develop |
100 ul |
EUR 270 |
|
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor |
Rabbit anti-IL-8 Antibody |
DL90596A-50ul |
DL Develop |
50 ul |
EUR 189 |
|
Description: CXCL8; Interleukin-8; IL-8; C-X-C motif chemokine 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factor |
Rabbit anti-IL-8 Antibody |
YLD4345-100ul |
Shanghai YL Biotech |
100 ul |
EUR 320 |
|
Description: Rabbit polyclonal antibody to IL-8 |
Rabbit anti-IL-8 Antibody |
YLD4345-50ul |
Shanghai YL Biotech |
50 ul |
EUR 200 |
|
Description: Rabbit polyclonal antibody to IL-8 |
Anti-IL-8 Monoclonal Antibody |
A00423-1 |
BosterBio |
100ul |
EUR 476.4 |
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat. |
human DIAplex Human Inflammation - IL-8, IL-17a, |
M880130004 |
Tecan Benelux |
1 unit |
EUR 650.27 |
Human IL-8 ELISA antibody pair |
CT748-10 |
U-CyTech |
10-plate |
EUR 656.4 |
Human IL-8 ELISA antibody pair |
CT748-20 |
U-CyTech |
20-plate |
EUR 1118.4 |
Anti-Human IL-8 (I8-S2) Antibody |
Y052802 |
ABM |
100 µg |
EUR 490 |
Anti-Human IL-17 (CTLA-8) Antibody |
101-M783 |
ReliaTech |
100 µg |
EUR 399 |
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries. |
Mouse Monoclonal anti-Human IL-8 Antibody |
xAP-0435 |
Angio Proteomie |
100ug |
EUR 280 |
Mouse Monoclonal anti-Human IL-8 Antibody |
xAP-0436 |
Angio Proteomie |
100ug |
EUR 280 |
Mouse Monoclonal anti-Human IL-8 Antibody |
xAP-0437 |
Angio Proteomie |
100ug |
EUR 280 |
Human Interleukin 8 (IL-8) CLIA Kit |
abx195916-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human IL-8 -Interleukin 8- CLIA Kit |
E-CL-H0048-24Tests |
Elabscience Biotech |
24 Tests |
EUR 180 |
|
Description: Sandwich |
Human IL-8 -Interleukin 8- CLIA Kit |
E-CL-H0048-48Tests |
Elabscience Biotech |
48 Tests |
EUR 546 |
|
Description: Sandwich |
Human IL-8 -Interleukin 8- CLIA Kit |
E-CL-H0048-96Tests |
Elabscience Biotech |
96 Tests |
EUR 682 |
|
Description: Sandwich |
Human IL-8 -Interleukin 8- CLIA Kit |
E-CL-H0048-96Tests10 |
Elabscience Biotech |
96 Tests *10 |
EUR 6820 |
|
Description: Sandwich |
Human IL-8 -Interleukin 8- CLIA Kit |
E-CL-H0048-96Tests5 |
Elabscience Biotech |
96 Tests *5 |
EUR 3410 |
|
Description: Sandwich |
mouse anti-human IL-8 mAb(Q10) |
E4A09D07-Q10 |
EnoGene |
50ug |
EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Human Interleukin 8(IL-8)ELISA Kit
CONCLUSIONS
Our outcomes point out that moxifloxacin acts as an anti-inflammatory agent in monocytic cells stimulated with A. fumigatus conidia. Whether or not these results could also be protecting as within the Candida pneumonia mannequin is unknown and deserves in vivo research in fashions of pulmonary aspergillosis.
Human pores and skin mast cells quickly launch preformed and newly generated TNF-alpha and IL-Eight following stimulation with anti-IgE and different secretagogues
- A number of teams have beforehand reported that rodent or human leukemic mast cells produce inflammatory cytokines akin to TNF-alpha and IL-Eight in addition to the pro-allergic cytokines IL-4, IL-5 and IL-13. Comparatively little is understood, nonetheless, relating to the flexibility of regular human pores and skin mast cells to secrete these components following both IgE-dependent or IgE-independent modes of activation.
CXCL8 Antibody, Biotin conjugated | CXCL8 Antibody, FITC conjugated
- We subsequently investigated whether or not regular human pores and skin mast cells produce these cytokines following stimulation by quite a lot of secretagogues. Enriched remoted pores and skin mast cells launched each TNF-alpha and IL-Eight following activation with both anti-IgE, SCF, substance P, compound 48/80 or A23187. This launch was dose- and time-dependent, with maximal ranges being reached inside Four h of stimulation involving, partly, the secretion of preformed shops of each cytokines.
Recombinant Human CXCL8 |
50190P-100 |
Genovis AB |
100ug |
EUR 551 |
Recombinant Human CXCL8 |
50190P-1000 |
Genovis AB |
1000ug |
EUR 2503 |
Recombinant Human CXCL8 |
50190P-20 |
Genovis AB |
20ug |
EUR 159 |
Recombinant Human CXCL8 |
50190P-5 |
Genovis AB |
5ug |
EUR 75 |
Recombinant Human CXCL8 |
50190P-50 |
Genovis AB |
50ug |
EUR 350 |
anti- CXCL8/IL8 antibody |
FNab09864 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against CXCL8/IL8 |
Anti-IL8/CXCL8 Antibody |
PB9621 |
BosterBio |
100ug/vial |
EUR 400.8 |
Human CXCL8 ELISA Kit |
STJ150098 |
St John's Laboratory |
1 kit |
EUR 494.4 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of IL-8 in human serum, plasma and other biological fluids |
Human Interleukin-8 (CXCL8) |
1-CSB-YP011671HU |
Cusabio |
-
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-
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-
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-
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-
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-
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|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in Yeast |
Human Interleukin-8 (CXCL8) |
1-CSB-EP011671HU |
Cusabio |
-
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-
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-
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-
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-
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-
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|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in E.coli |
Recombinant Human CXCL8, biotinylated |
50190PB |
Genovis AB |
10ug |
EUR 624 |
Recombinant Human CXCL8, biotinylated |
50190PB-10 |
Genovis AB |
10ug |
EUR 624 |
Recombinant Human CXCL8, biotinylated |
50190PB-100 |
Genovis AB |
100ug |
EUR 3852 |
Recombinant Human CXCL8, biotinylated |
50190PB-2 |
Genovis AB |
2ug |
EUR 153 |
Recombinant Human CXCL8, biotinylated |
50190PB-50 |
Genovis AB |
50ug |
EUR 2302 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1200 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1201 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1203 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1204 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH1205 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, Fc Tag |
E40KMPH5724 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein, His Tag |
E40KMPH1202 |
EnoGene |
20ug |
EUR 495 |
Human CXCL8 Protein Lysate 20ug |
IHUCXCL8PLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human CXCL8 Protein Lysate 20ug |
CXCL8 Antibody |
1-CSB-PA009564 |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
CXCL8 Antibody |
E912452 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
CXCL8 Antibody |
E91289 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
CXCL8 Antibody |
1-CSB-PA003036 |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA004977 |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA011671GA01HU |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
CXCL8 Antibody |
1-CSB-PA011671YA01DO |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 antibody |
70R-21501 |
Fitzgerald |
50 ul |
EUR 289 |
|
Description: Rabbit polyclonal CXCL8 antibody |
CXCL8 Antibody |
1-CSB-PA08327A0Rb |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
CXCL8 Antibody |
1-CSB-PA08329A0Rb |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
CXCL8 Antibody |
1-CSB-PA15789A0Rb |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
K06289U04B05C-100ug |
Absea Biotechnology |
100 ug |
EUR 360 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U04B05C-1mg |
Absea Biotechnology |
1 mg |
EUR 1800 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U04B05C-50ug |
Absea Biotechnology |
50 ug |
EUR 252 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U04D08C-100ug |
Absea Biotechnology |
100 ug |
EUR 280 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U04D08C-1mg |
Absea Biotechnology |
1 mg |
EUR 1400 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U04D08C-50ug |
Absea Biotechnology |
50 ug |
EUR 196 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09D11C-100ug |
Absea Biotechnology |
100 ug |
EUR 280 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09D11C-1mg |
Absea Biotechnology |
1 mg |
EUR 1400 |
|
Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09D11C-50ug |
Absea Biotechnology |
50 ug |
EUR 196 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09F03C-100ug |
Absea Biotechnology |
100 ug |
EUR 440 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09F03C-1mg |
Absea Biotechnology |
1 mg |
EUR 2200 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U09F03C-50ug |
Absea Biotechnology |
50 ug |
EUR 308 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U10A11C-100ug |
Absea Biotechnology |
100 ug |
EUR 360 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U10A11C-1mg |
Absea Biotechnology |
1 mg |
EUR 1800 |
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Description: Monoclonal Antibody |
CXCL8 Antibody |
K06289U10A11C-50ug |
Absea Biotechnology |
50 ug |
EUR 252 |
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Description: Monoclonal Antibody |
Mouse Monoclonal anti-human CXCL8 (IL-8) |
hAP-0219 |
Angio Proteomie |
100ug |
EUR 250 |
Sheep Polyclonal anti-human CXCL8 (IL-8) |
hAP-5118 |
Angio Proteomie |
50ug |
EUR 400 |
Human IL-8/CXCL8 Antibody Pair Set |
ABPR-ZB076 |
Creative Diagnostics |
5 plates, 15 plates |
Ask for price |
Description: Quantitative determination of Human IL-8/CXCL8 |
CXCL8 ELISA Kit (Human) (OKAN04343) |
OKAN04343 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04344) |
OKAN04344 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04345) |
OKAN04345 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL |
Human Interleukin 8 (CXCL8) Protein |
abx694105-10nmol |
Abbexa |
10 nmol |
EUR 400 |
Human Interleukin 8 (CXCL8) Protein |
abx694105-5nmol |
Abbexa |
5 nmol |
EUR 300 |
Anti-equine IL-8 (CXCL8) PAb |
GWB-KI0060 |
GenWay Biotech |
1 kit |
Ask for price |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100008 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100009 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
Human CXCL8 Recombinant Protein Lyophilized |
IHUCXCL8RLY5UG |
Innovative research |
each |
EUR 341 |
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Description: Human CXCL8 Recombinant Protein Lyophilized |
Anti-human IL-8 (CXCL8) mAb (26E5), biotin |
3560-14-1000 |
Mabtech AB |
1 mg |
EUR 1044.75 |
Anti-human IL-8 (CXCL8) mAb (26E5), biotin |
3560-14-250 |
Mabtech AB |
250 µg |
EUR 283.5 |
Human IL-8/CXCL8 ELISA Kit |
RK00011 |
Abclonal |
96 Tests |
EUR 280 |
Recombinant Human Interleukin-8(CXCL8) |
AP77798 |
SAB |
each |
Ask for price |
|
Anti-human IL-8 (CXCL8) mAb (MT8F19), biotin |
3560-6-1000 |
Mabtech AB |
1 mg |
EUR 1044.75 |
Anti-human IL-8 (CXCL8) mAb (MT8F19), biotin |
3560-6-250 |
Mabtech AB |
250 µg |
EUR 283.5 |
Human CXCL8/ Interleukin-8 ELISA Kit |
E0623Hu |
Sunlong |
1 Kit |
EUR 515 |
|
Description: IL8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,Monocyte-derived neutrophil chemotactic factor,Monocyte-derived neutrophil-activating peptide,Neutrophil-activating protein 1,Protein 3-10C,T-cell chemotactic factor,GCP-1,MDNCF,MONAP,NAP-1 |
Human CXCL8 / Interleukin-8 ELISA Kit |
E0080h |
EIAab |
96T |
EUR 536 |
Anti-human IL-8 (CXCL8) mAb (MT8H6), unconjugated |
3560-3-1000 |
Mabtech AB |
1 mg |
EUR 840 |
Anti-human IL-8 (CXCL8) mAb (MT8H6), unconjugated |
3560-3-250 |
Mabtech AB |
250 µg |
EUR 241.5 |
IL-8/CXCL8 (CHO-expressed), Human |
HY-P7379 |
MedChemExpress |
50ug |
EUR 596.4 |
Human Interleukin 8 / IL8 (CXCL8) Protein |
20-abx260688 |
Abbexa |
-
Ask for price
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Human Interleukin 8 / IL8 (CXCL8) Protein |
abx260688-10g |
Abbexa |
10 µg |
EUR 325 |
Human Interleukin 8 / IL8 (CXCL8) Protein |
abx260688-2g |
Abbexa |
2 µg |
EUR 225 |
Human IL-8 / CXCL8 Protein, Fc Tag |
IL8-H5258 |
ACROBIOSYSTEMS |
100ug |
EUR 2749.9 |
|
Description: Human IL-8, Fc Tag (IL8-H5258) is expressed from human 293 cells (HEK293). It contains AA Ser 28 - Ser 99 (Accession # P10145-1). |
CXCL8 Polyclonal Antibody |
E92541 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
CXCL8 Polyclonal Antibody |
A55395 |
EpiGentek |
-
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|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A51853 |
EpiGentek |
-
Ask for price
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- 100 µg
- 20 ul
- 50 ul
- 100 ul
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- In accordance with this, utilizing lysates of extremely purified (>90%) pores and skin mast cells, we might display that each TNF-alpha and IL-Eight mRNA and protein had been current in each unstimulated in addition to stimulated mast cells. In stark distinction to those outcomes, no important ranges of both IL-4, IL-5 or IL-13 had been detected, whatever the secretagogue used or the interval of stimulation.
- These outcomes present that human pores and skin mast cells are able to quickly secreting pro-inflammatory cytokines like TNF-alpha and IL-Eight following IgE-dependent activation and stimulation by the neuropeptide substance P, SCF and the essential polypeptide analogue compound 48/80. In distinction to different forms of human mast cells nonetheless, human pores and skin mast cells had been incapable of secreting IL-4, IL-5 or IL-13 in these settings.