Anti-inflammatory results of moxifloxacin on IL8IL-1beta and TNF-alpha secretion and NF kappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus
OBJECTIVE
We now have beforehand proven that moxifloxacin conferred protecting anti-inflammatory results in opposition to Candida pneumonia in immunosuppressed mice. Additional in vitro research confirmed anti-inflammatory results of moxifloxacin in LPS and cytokine-stimulated monocytic and epithelial cells. Within the current examine, concentrating on a more difficult pathogen of immunosuppressed hosts, we studied the impact of moxifloxacin on cytokine secretion and sign transduction mechanisms in monocytic cells stimulated with Aspergillus fumigatus.
METHODS
Human peripheral blood monocytes (PBMCs) and a human monocytic cell line (THP-1) had been incubated with 1.5×10(6)/mL conidia of a scientific isolate of A. fumigatus. Cytokine secretion and activation of NFkappaB and the MAP-kinases ERK1/2 and p38 had been measured with and with out the addition of moxifloxacin (5-20 mg/L).
Human Interleukin-8 (IL-8) Antibody
RESULTS
Stimulation of PBMCs and THP-1 cells with A. fumigatus elevated IL-8, IL-1beta and TNF-alpha secretion (4.1-, 8.3- and 7-fold, and 5.4-, 3.7- and 17.8-fold, respectively). Addition of moxifloxacin (5-20 mg/L) inhibited cytokine secretion as much as 45.7+/-5%, 72+/-13% and 73+/-10% in PBMCs and as much as 35.6+/-0.5%, 30+/-2.4% and 19+/-4% in THP-1 cells (P<0.05). Sign transduction research confirmed that incubation of THP-1 cells with A. fumigatus elevated ERK1/2 and p38 phosphorylation and p65-NFkappaB protein expression by 1.6-, 1.3- and 1.8-fold, respectively. Addition of moxifloxacin inhibited ERK1/2, p38 and p65-NFkappaB by as much as 69+/-14%, 58+/-3% and 75+/-15%, respectively.
Anti-IL-8 antibody |
STJ97720 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ98175 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to IL-8. |
1730 8 SNAP-SEAL 8 OZ |
1730-8 |
CORNING |
100/pk |
EUR 88.8 |
Description: Disposable Plastic; Plastic Containers |
mAb mouse anti-human IL-8 |
CT264 |
U-CyTech |
0.5 mg |
EUR 312 |
Anti-IL-8 Monoclonal Antibody |
A00423-1 |
BosterBio |
100ul |
EUR 476.4 |
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat. |
Individual Reaction Mix 8 |
G065-8 |
ABM |
200 reactions |
EUR 200.4 |
Swine IL-6 Recombinant Protein |
R00102-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Swine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast. |
Swine IL-4 Recombinant Protein |
R00230-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Swine IL-4 Recombinant Protein is purified interleukin-4 produced in yeast. |
Rabbit IL-2 Recombinant Protein |
R00387-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Rabbit IL-2 Recombinant Protein is purified interleukin-2 produced in yeast. |
Swine IL-17A Recombinant Protein |
R00421-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Swine IL-17A Recombinant Protein is purified interleukin-17A produced in yeast. |
Human Interleukin-8 (IL-8) Antibody |
13102-05011 |
AssayPro |
150 ug |
EUR 248.4 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
Human IL-8 Antibody |
33486-05111 |
AssayPro |
150 ug |
EUR 313.2 |
Human IL-8 Protein |
abx060803-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 Protein |
abx060804-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Recombinant Human IL-8 |
P0180 |
FN Test |
100ug |
EUR 626.83 |
|
Description: Recombinant Human protein for IL-8 |
Recombinant Human IL-8 |
SJB05-01 |
Amyotop |
25µg/vial |
EUR 342 |
Ovine IL-1 beta Recombinant Protein |
R00101-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Ovine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
Human THSD7a ELISA kit |
8-E01A2155 |
BlueGene |
-
EUR 1524.00
-
EUR 624.00
-
EUR 822.00
|
- 192 tests
- 1 plate of 48 wells
- 1 plate of 96 wells
|
|
Description: A competitive ELISA for quantitative measurement of Human THSD7a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100008 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100009 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
CXCL8/IL-8 |
E21-C97 |
EnoGene |
10ug |
EUR 411.6 |
CXCL8/IL-8 |
GT15156 |
Neuromics |
100 ug |
EUR 631.2 |
IL-8 Inhibitor |
H-2268.0001 |
Bachem |
1.0mg |
EUR 200.4 |
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
IL-8 Inhibitor |
H-2268.0005 |
Bachem |
5.0mg |
EUR 691.2 |
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
IL-8 Inhibitor |
H-2268.0025 |
Bachem |
25.0mg |
EUR 2648.4 |
Description: Sum Formula: C45H66N18O7S; CAS# [138559-60-1] net |
IL-8, Interleukin-8, monkey |
RC222-19 |
Bio Basic |
5ug |
EUR 125.26 |
|
Human Interleukin 8, IL-8 ELISA KIT |
CSB-E04641h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 8, IL-8 ELISA KIT |
1-CSB-E04641h |
Cusabio |
-
EUR 600.00
-
EUR 4082.40
-
EUR 2184.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Interleukin 8(IL-8)ELISA Kit |
GA-E0129HM-48T |
GenAsia Biotech |
48T |
EUR 346.8 |
Human Interleukin 8(IL-8)ELISA Kit |
GA-E0129HM-96T |
GenAsia Biotech |
96T |
EUR 559.2 |
Human Interleukin 8,IL-8 ELISA KIT |
201-12-0090 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Interleukin 8 (IL-8) CLIA Kit |
abx195916-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Interleukin-8 (IL-8) ELISA Kit |
LF-EK60006 |
Abfrontier |
1×96T |
EUR 948 |
Human IL-8(Interleukin 8) ELISA Kit |
EH0205 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
Human IL-8 ELISA kit |
CT212A |
U-CyTech |
5-plate |
EUR 554.4 |
Human IL-8 ELISA Kit |
EHI0063 |
Abclonal |
96Tests |
EUR 625.2 |
Human IL-8 ELISA kit |
LF-EK50165 |
Abfrontier |
1×96T |
EUR 777.6 |
human IL-8 His tag |
E410A07-100 |
EnoGene |
100μg |
EUR 1152 |
rec Endothelial IL-8 (human) |
H-3742.0010 |
Bachem |
10.0µg |
EUR 340.8 |
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
rec Endothelial IL-8 (human) |
H-3742.0050 |
Bachem |
50.0µg |
EUR 1167.6 |
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
IL-8 (Human) ELISA Kit |
K4169-100 |
Biovision |
|
EUR 874.8 |
rec Monocyte IL-8 (human) |
H-9625.0005 |
Bachem |
5.0µg |
EUR 194.4 |
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
rec Monocyte IL-8 (human) |
H-9625.0025 |
Bachem |
25.0µg |
EUR 457.2 |
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
Recombinant Human IL-8 Protein |
RP00052 |
Abclonal |
5 μg |
EUR 178.8 |
IL-8, CXCL8, Interleukin-8, canine |
RC242-19 |
Bio Basic |
5ug |
EUR 125.26 |
|
IL-8, CXCL8, Interleukin-8, porcine |
RC282-19 |
Bio Basic |
5ug |
EUR 125.26 |
|
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-10ug |
Novoprotein |
10ug |
EUR 175.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Human Interleukin 8(IL-8)ELISA Kit
CONCLUSIONS
Our outcomes point out that moxifloxacin acts as an anti-inflammatory agent in monocytic cells stimulated with A. fumigatus conidia. Whether or not these results could also be protecting as within the Candida pneumonia mannequin is unknown and deserves in vivo research in fashions of pulmonary aspergillosis.
Human pores and skin mast cells quickly launch preformed and newly generated TNF-alpha and IL-Eight following stimulation with anti-IgE and different secretagogues
- A number of teams have beforehand reported that rodent or human leukemic mast cells produce inflammatory cytokines akin to TNF-alpha and IL-Eight in addition to the pro-allergic cytokines IL-4, IL-5 and IL-13. Comparatively little is understood, nonetheless, relating to the flexibility of regular human pores and skin mast cells to secrete these components following both IgE-dependent or IgE-independent modes of activation.
CXCL8 Antibody, Biotin conjugated | CXCL8 Antibody, FITC conjugated
- We subsequently investigated whether or not regular human pores and skin mast cells produce these cytokines following stimulation by quite a lot of secretagogues. Enriched remoted pores and skin mast cells launched each TNF-alpha and IL-Eight following activation with both anti-IgE, SCF, substance P, compound 48/80 or A23187. This launch was dose- and time-dependent, with maximal ranges being reached inside Four h of stimulation involving, partly, the secretion of preformed shops of each cytokines.
Anti-CXCL8 antibody |
STJ400116 |
St John's Laboratory |
1 mg |
EUR 535.2 |
Description: Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. Primary function of IL-8 is the induction of chemotaxis in its target cells (e.g. neutrophil granulocytes). It serves as a chemical signal that attracts neutrophils at the site of inflammation. IL-8 is a promising marker for many clinical conditions and currently being applied by various subspecialties of medicine either for the purpose of rapid diagnosis or as a predictor of prognosis. IL-8 level increases as a result of many inflammatory conditions, so careful interpretation of IL-8 level is required to make correlation with desired clinical condition's diagnosis or prognosis. |
Anti-CXCL8 antibody |
STJ24194 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
anti- CXCL8/IL8 antibody |
FNab09864 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against CXCL8/IL8 |
Anti-IL8/CXCL8 Antibody |
PA1353 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-IL8/CXCL8 Antibody |
PB9621 |
BosterBio |
100ug/vial |
EUR 400.8 |
CXCL8 antibody |
70R-21501 |
Fitzgerald |
50 ul |
EUR 522 |
Description: Rabbit polyclonal CXCL8 antibody |
CXCL8 Antibody |
1-CSB-PA08327A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
CXCL8 Antibody |
1-CSB-PA08329A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
CXCL8 Antibody |
1-CSB-PA15789A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
1-CSB-PA004977 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA011671GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
CXCL8 Antibody |
1-CSB-PA011671YA01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
1-CSB-PA003036 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA009564 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
Human Interleukin-8 (CXCL8) |
1-CSB-EP011671HU |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in E.coli |
Human Interleukin-8 (CXCL8) |
1-CSB-YP011671HU |
Cusabio |
-
EUR 516.00
-
EUR 280.80
-
EUR 1809.60
-
EUR 770.40
-
EUR 1210.80
-
EUR 349.20
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in Yeast |
Human CXCL8 ELISA Kit |
STJ150098 |
St John's Laboratory |
1 kit |
EUR 494.4 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of IL-8 in human serum, plasma and other biological fluids |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 336 |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100008 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100009 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
CXCL8 Recombinant Protein |
40-105-0005mg |
ProSci |
0.005 mg |
EUR 311.1 |
Description: CXCL8 (IL-8) is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. CXCL8 (IL-8) chemoattracts and activates neutrophils. Recombinant human CXCL8 (IL-8) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues. |
CXCL8 Recombinant Protein |
40-105-0025mg |
ProSci |
0.025 mg |
EUR 437.1 |
Description: CXCL8 (IL-8) is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. CXCL8 (IL-8) chemoattracts and activates neutrophils. Recombinant human CXCL8 (IL-8) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues. |
CXCL8 Recombinant Protein |
91-874 |
ProSci |
0.05 mg |
EUR 619.8 |
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. |
CXCL8/IL-8 |
E21-C97 |
EnoGene |
10ug |
EUR 411.6 |
CXCL8/IL-8 |
GT15156 |
Neuromics |
100 ug |
EUR 631.2 |
CXCL8 Polyclonal Antibody |
A55395-020 |
EpiGentek |
20 ul |
EUR 117.7 |
CXCL8 Polyclonal Antibody |
A55395-050 |
EpiGentek |
50 ul |
EUR 302.5 |
CXCL8 Polyclonal Antibody |
A55395-100 |
EpiGentek |
100 ul |
EUR 423.5 |
CXCL8 Polyclonal Antibody |
A55395 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A51853 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A52034 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A51853-020 |
EpiGentek |
20 ul |
Ask for price |
CXCL8 Polyclonal Antibody |
A51853-050 |
EpiGentek |
50 ul |
Ask for price |
CXCL8 Polyclonal Antibody |
A51853-100 |
EpiGentek |
100 ul |
EUR 423.5 |
CXCL8 Polyclonal Antibody |
A52034-020 |
EpiGentek |
20 ul |
EUR 117.7 |
CXCL8 Polyclonal Antibody |
A52034-050 |
EpiGentek |
50 ul |
EUR 302.5 |
CXCL8 Polyclonal Antibody |
A52034-100 |
EpiGentek |
100 ul |
EUR 423.5 |
CXCL8 ELISA Kit (Human) (OKAN04343) |
OKAN04343 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04344) |
OKAN04344 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04345) |
OKAN04345 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL |
Human Interleukin 8 / IL8 (CXCL8) Protein |
20-abx260688 |
Abbexa |
-
EUR 4101.60
-
EUR 393.60
-
EUR 276.00
|
|
|
Human CXCL8/ Interleukin-8 ELISA Kit |
E0623Hu |
Sunlong |
1 Kit |
EUR 582 |
IL-8/CXCL8 (CHO-expressed), Human |
HY-P7379 |
MedChemExpress |
50ug |
EUR 596.4 |
Human IL-8/CXCL8 ELISA Kit |
RK00011 |
Abclonal |
96 Tests |
EUR 625.2 |
Chicken Interleukin-8 (CXCL8) |
1-CSB-EP011671CH1 |
Cusabio |
-
EUR 733.20
-
EUR 370.80
-
EUR 2192.40
-
EUR 1126.80
-
EUR 1461.60
-
EUR 476.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Chicken Interleukin-8(CXCL8),partial expressed in E.coli |
chicken Interleukin-8 (CXCL8) |
1-CSB-EP011671CH1e1 |
Cusabio |
-
EUR 872.40
-
EUR 510.00
-
EUR 2331.60
-
EUR 1266.00
-
EUR 1602.00
-
EUR 615.60
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant chicken Interleukin-8(CXCL8),partial expressed in E.coli |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA08327B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA08327C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA08327D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA08329B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA08329C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA08329D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA15789B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA15789C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA15789D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA011671YB01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA011671YC01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA011671YD01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01906 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01907 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01908 |
CHI Scientific |
1mg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01912 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01913 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01914 |
CHI Scientific |
1mg |
Ask for price |
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
20-abx152049 |
Abbexa |
-
EUR 6373.20
-
EUR 3404.40
-
EUR 801.60
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
20-abx156661 |
Abbexa |
-
EUR 6768.00
-
EUR 3610.80
-
EUR 848.40
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx050129-96tests |
Abbexa |
96 tests |
EUR 745.2 |
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx251378-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx574561-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
CXCL8 Chemi-Luminescent ELISA Kit (Human) (OKCD03689) |
OKCD03689 |
Aviva Systems Biology |
96 Wells |
EUR 1185.6 |
Description: Description of target: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.37 pg/mL |
IL-8 / CXCL8 Recombinant Protein |
11-160 |
ProSci |
0.1 mg |
EUR 714.3 |
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. |
IL-8 / CXCL8 Recombinant Protein |
11-219 |
ProSci |
0.1 mg |
EUR 714.3 |
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. |
IL-8 / CXCL8 Recombinant Protein |
11-355 |
ProSci |
0.1 mg |
EUR 714.3 |
Description: Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. |
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx100968 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1412.40
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx001979 |
Abbexa |
-
EUR 493.20
-
EUR 126.00
-
EUR 710.40
-
EUR 218.40
|
- 100 ul
- 10 ul
- 200 ul
- 50 ul
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx109944 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx110542 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx110581 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx113257 |
Abbexa |
|
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
abx011005-100ul |
Abbexa |
100 ul |
EUR 493.2 |
|
- In accordance with this, utilizing lysates of extremely purified (>90%) pores and skin mast cells, we might display that each TNF-alpha and IL-Eight mRNA and protein had been current in each unstimulated in addition to stimulated mast cells. In stark distinction to those outcomes, no important ranges of both IL-4, IL-5 or IL-13 had been detected, whatever the secretagogue used or the interval of stimulation.
- These outcomes present that human pores and skin mast cells are able to quickly secreting pro-inflammatory cytokines like TNF-alpha and IL-Eight following IgE-dependent activation and stimulation by the neuropeptide substance P, SCF and the essential polypeptide analogue compound 48/80. In distinction to different forms of human mast cells nonetheless, human pores and skin mast cells had been incapable of secreting IL-4, IL-5 or IL-13 in these settings.