Anti-inflammatory results of moxifloxacin on IL8IL-1beta and TNF-alpha secretion and NF kappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus
OBJECTIVE
We now have beforehand proven that moxifloxacin conferred protecting anti-inflammatory results in opposition to Candida pneumonia in immunosuppressed mice. Additional in vitro research confirmed anti-inflammatory results of moxifloxacin in LPS and cytokine-stimulated monocytic and epithelial cells. Within the current examine, concentrating on a more difficult pathogen of immunosuppressed hosts, we studied the impact of moxifloxacin on cytokine secretion and sign transduction mechanisms in monocytic cells stimulated with Aspergillus fumigatus.
METHODS
Human peripheral blood monocytes (PBMCs) and a human monocytic cell line (THP-1) had been incubated with 1.5×10(6)/mL conidia of a scientific isolate of A. fumigatus. Cytokine secretion and activation of NFkappaB and the MAP-kinases ERK1/2 and p38 had been measured with and with out the addition of moxifloxacin (5-20 mg/L).
Human Interleukin-8 (IL-8) Antibody
RESULTS
Stimulation of PBMCs and THP-1 cells with A. fumigatus elevated IL-8, IL-1beta and TNF-alpha secretion (4.1-, 8.3- and 7-fold, and 5.4-, 3.7- and 17.8-fold, respectively). Addition of moxifloxacin (5-20 mg/L) inhibited cytokine secretion as much as 45.7+/-5%, 72+/-13% and 73+/-10% in PBMCs and as much as 35.6+/-0.5%, 30+/-2.4% and 19+/-4% in THP-1 cells (P<0.05). Sign transduction research confirmed that incubation of THP-1 cells with A. fumigatus elevated ERK1/2 and p38 phosphorylation and p65-NFkappaB protein expression by 1.6-, 1.3- and 1.8-fold, respectively. Addition of moxifloxacin inhibited ERK1/2, p38 and p65-NFkappaB by as much as 69+/-14%, 58+/-3% and 75+/-15%, respectively.
Anti-IL-8 antibody |
STJ97710 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ97717 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ97720 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Mouse monoclonal to IL-8. |
Anti-IL-8 antibody |
STJ98175 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to IL-8. |
anti-IL-8 (3E4D8) |
LF-MA30011 |
Abfrontier |
100 ul |
EUR 448.8 |
Description: Mouse Monoclonal to IL-8 |
mAb mouse anti-human IL-8 |
CT264 |
U-CyTech |
0.5 mg |
EUR 312 |
Human IL-8 Protein |
abx060803-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Human IL-8 Protein |
abx060804-25ug |
Abbexa |
25 ug |
EUR 644.4 |
|
Recombinant Human IL-8 |
P0180 |
FN Test |
100ug |
EUR 626.83 |
|
Description: Recombinant Human protein for IL-8 |
Recombinant Human IL-8 |
SJB05-01 |
Amyotop |
25µg/vial |
EUR 342 |
Anti-IL-8 Monoclonal Antibody |
A00423-1 |
BosterBio |
100ul |
EUR 476.4 |
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat. |
Human Interleukin-8 (IL-8) Antibody (Biotin Conjugate) |
13102-05021 |
AssayPro |
150 ug |
EUR 313.2 |
Human IL-8 ELISA antibody pair |
CT748-10 |
U-CyTech |
10-plate |
EUR 656.4 |
Human IL-8 ELISA antibody pair |
CT748-20 |
U-CyTech |
20-plate |
EUR 1118.4 |
Human IL-8 Antibody (Biotin Conjugate) |
33486-05121 |
AssayPro |
150 ug |
EUR 442.8 |
Human Interleukin 8 (IL-8) CLIA Kit |
abx195916-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Interleukin 8,IL-8 ELISA KIT |
201-12-0090 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Interleukin 8, IL-8 ELISA KIT |
CSB-E04641h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid (CSF), tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 8, IL-8 ELISA KIT |
1-CSB-E04641h |
Cusabio |
-
EUR 600.00
-
EUR 4082.40
-
EUR 2184.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitative sandwich ELISA kit for measuring Human Interleukin 8, IL-8 in samples from serum, cell culture supernates, saliva, urine, cerebrospinalfluid(CSF), tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Interleukin 8(IL-8)ELISA Kit |
GA-E0129HM-48T |
GenAsia Biotech |
48T |
EUR 346.8 |
Human Interleukin 8(IL-8)ELISA Kit |
GA-E0129HM-96T |
GenAsia Biotech |
96T |
EUR 559.2 |
Human IL-8(Interleukin 8) ELISA Kit |
EH0205 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
Human Interleukin-8 (IL-8) ELISA Kit |
LF-EK60006 |
Abfrontier |
1×96T |
EUR 948 |
human IL-8 His tag |
E410A07-100 |
EnoGene |
100μg |
EUR 1152 |
Human IL-8 ELISA kit |
CT212A |
U-CyTech |
5-plate |
EUR 554.4 |
Human IL-8 ELISA kit |
LF-EK50165 |
Abfrontier |
1×96T |
EUR 777.6 |
Human IL-8 ELISA Kit |
EHI0063 |
Abclonal |
96Tests |
EUR 625.2 |
IL-8 (Human) ELISA Kit |
K4169-100 |
Biovision |
each |
EUR 874.8 |
Human Interleukin-8 (IL-8) AssayLite Antibody (RPE Conjugate) |
13102-05051 |
AssayPro |
150 ug |
EUR 513.6 |
Human Interleukin-8 (IL-8) AssayLite Antibody (APC Conjugate) |
13102-05061 |
AssayPro |
150 ug |
EUR 513.6 |
Human Interleukin-8 (IL-8) AssayLite Antibody (FITC Conjugate) |
13102-05041 |
AssayPro |
150 ug |
EUR 513.6 |
Human Interleukin-8 (IL-8) AssayLite Antibody (PerCP Conjugate) |
13102-05071 |
AssayPro |
150 ug |
EUR 565.2 |
rec Monocyte IL-8 (human) |
H-9625.0005 |
Bachem |
5.0µg |
EUR 194.4 |
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
rec Monocyte IL-8 (human) |
H-9625.0025 |
Bachem |
25.0µg |
EUR 457.2 |
Description: Sum Formula: C372H600N106O106S4; CAS# [142298-00-8] |
rec Endothelial IL-8 (human) |
H-3742.0010 |
Bachem |
10.0µg |
EUR 340.8 |
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
rec Endothelial IL-8 (human) |
H-3742.0050 |
Bachem |
50.0µg |
EUR 1167.6 |
Description: Sum Formula: C397H644N114O111S4; CAS# [142298-01-9] |
Recombinant Human IL-8 (72a.a.) |
HEILP-0801 |
Cyagen |
5ug |
Ask for price |
Recombinant Human IL-8 (77a.a.) |
HEILP-0802 |
Cyagen |
5ug |
Ask for price |
Recombinant Human IL-8 Protein |
RP00052 |
Abclonal |
5 μg |
EUR 178.8 |
Human IL-8 Recombinant Protein |
R00423-8 |
BosterBio |
5ug/vial |
EUR 310.8 |
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100008 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100009 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
CLIA kit for Human IL-8 (Interleukin 8) |
E-CL-H0048 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant |
IL-8, CXCL8, Interleukin-8 (72 a.a.), human |
RC212-19A |
Bio Basic |
5ug |
EUR 125.26 |
|
IL-8, CXCL8, Interleukin-8 (77 a.a.), human |
RC212-19B |
Bio Basic |
5ug |
EUR 125.26 |
|
IL-8 Antibody |
5149-100 |
Biovision |
each |
EUR 405.6 |
IL-8 Antibody |
F51235-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: IL8 is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. |
IL-8 Antibody |
F51235-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: IL8 is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. |
IL-8 Antibody |
R30420 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-8(IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8(IL8) is a member of the CXC chemokine family(Hull et al., 2001). IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment. |
IL-8 Antibody |
R31932 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8 (IL8) is a member of the CXC chemokine family. IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment. |
ELISA kit for Human IL-8 (Interleukin 8) |
E-EL-H0048 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 452.4 |
|
Description: A sandwich ELISA kit for quantitative measurement of Human IL-8 (Interleukin 8) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Human Interleukin 8,IL-8 |
EK0240 |
SAB |
96 tests |
EUR 723.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Interleukin 8,IL-8 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Human Interleukin-8 (IL-8) AssayMax ELISA Kit |
EI1008-1 |
AssayPro |
96 Well Plate |
EUR 572.4 |
Human IL-8 AssayLite Antibody (RPE Conjugate) |
33486-05151 |
AssayPro |
150 ug |
EUR 513.6 |
Human IL-8 AssayLite Antibody (APC Conjugate) |
33486-05161 |
AssayPro |
150 ug |
EUR 513.6 |
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-10ug |
Novoprotein |
10ug |
EUR 175.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Recombinant Human Interleukin-8/IL-8 (C-6His) |
CC97-50ug |
Novoprotein |
50ug |
EUR 406.8 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
Human Interleukin 8(IL-8)ELISA Kit
CONCLUSIONS
Our outcomes point out that moxifloxacin acts as an anti-inflammatory agent in monocytic cells stimulated with A. fumigatus conidia. Whether or not these results could also be protecting as within the Candida pneumonia mannequin is unknown and deserves in vivo research in fashions of pulmonary aspergillosis.
Human pores and skin mast cells quickly launch preformed and newly generated TNF-alpha and IL-Eight following stimulation with anti-IgE and different secretagogues
- A number of teams have beforehand reported that rodent or human leukemic mast cells produce inflammatory cytokines akin to TNF-alpha and IL-Eight in addition to the pro-allergic cytokines IL-4, IL-5 and IL-13. Comparatively little is understood, nonetheless, relating to the flexibility of regular human pores and skin mast cells to secrete these components following both IgE-dependent or IgE-independent modes of activation.
CXCL8 Antibody, Biotin conjugated | CXCL8 Antibody, FITC conjugated
- We subsequently investigated whether or not regular human pores and skin mast cells produce these cytokines following stimulation by quite a lot of secretagogues. Enriched remoted pores and skin mast cells launched each TNF-alpha and IL-Eight following activation with both anti-IgE, SCF, substance P, compound 48/80 or A23187. This launch was dose- and time-dependent, with maximal ranges being reached inside Four h of stimulation involving, partly, the secretion of preformed shops of each cytokines.
Anti-IL8/CXCL8 Antibody |
PB9621 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-IL8/CXCL8 Antibody |
PA1353 |
BosterBio |
100ug/vial |
EUR 400.8 |
Human CXCL8 ELISA Kit |
STJ150098 |
St John's Laboratory |
1 kit |
EUR 494.4 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of IL-8 in human serum, plasma and other biological fluids |
Human Interleukin-8 (CXCL8) |
1-CSB-YP011671HU |
Cusabio |
-
EUR 516.00
-
EUR 280.80
-
EUR 1809.60
-
EUR 770.40
-
EUR 1210.80
-
EUR 349.20
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in Yeast |
Human Interleukin-8 (CXCL8) |
1-CSB-EP011671HU |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Interleukin-8(CXCL8),partial expressed in E.coli |
CXCL8 antibody |
70R-21501 |
Fitzgerald |
50 ul |
EUR 522 |
Description: Rabbit polyclonal CXCL8 antibody |
CXCL8 Antibody |
1-CSB-PA009564 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
CXCL8 Antibody |
1-CSB-PA15789A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
1-CSB-PA004977 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
CXCL8 Antibody |
1-CSB-PA08327A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
CXCL8 Antibody |
1-CSB-PA08329A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
CXCL8 Antibody |
1-CSB-PA011671GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
CXCL8 Antibody |
1-CSB-PA011671YA01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Unconjugated. Tested in the following application: ELISA |
CXCL8 Antibody |
1-CSB-PA003036 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100008 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: These monoclonal antibodies enable sensitive and specific detection of bovine IL-8 in ELISpot. |
Anti-bovine IL-8 (CXCL8) antibody |
STJ15100009 |
St John's Laboratory |
250 µg |
EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of bovine IL-8 in ELISA. |
CXCL8 ELISA Kit (Human) (OKAN04343) |
OKAN04343 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04344) |
OKAN04344 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL |
CXCL8 ELISA Kit (Human) (OKAN04345) |
OKAN04345 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL |
Human IL-8/CXCL8 ELISA Kit |
RK00011 |
Abclonal |
96 Tests |
EUR 625.2 |
CXCL8 Polyclonal Antibody |
A55395 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A51853 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
CXCL8 Polyclonal Antibody |
A52034 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
Human CXCL8/ Interleukin-8 ELISA Kit |
E0623Hu |
Sunlong |
1 Kit |
EUR 582 |
IL-8/CXCL8 (CHO-expressed), Human |
HY-P7379 |
MedChemExpress |
50ug |
EUR 596.4 |
Human Interleukin 8 / IL8 (CXCL8) Protein |
20-abx260688 |
Abbexa |
-
EUR 4101.60
-
EUR 393.60
-
EUR 276.00
|
|
|
CXCL8/IL-8 |
GT15156 |
Neuromics |
100 ug |
EUR 631.2 |
CXCL8/IL-8 |
E21-C97 |
EnoGene |
10ug |
EUR 411.6 |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA15789B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA08327B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA08329B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, HRP conjugated |
1-CSB-PA011671YB01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is HRP conjugated. Tested in the following application: ELISA |
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
20-abx152049 |
Abbexa |
-
EUR 6373.20
-
EUR 3404.40
-
EUR 801.60
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx251378-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx050129-96tests |
Abbexa |
96 tests |
EUR 745.2 |
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
abx574561-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
Human Interleukin 8 / IL8 (CXCL8) ELISA Kit |
20-abx156661 |
Abbexa |
-
EUR 6768.00
-
EUR 3610.80
-
EUR 848.40
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
CXCL8 Antibody, FITC conjugated |
1-CSB-PA15789C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA08327C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA08329C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, FITC conjugated |
1-CSB-PA011671YC01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is FITC conjugated. Tested in the following application: ELISA |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01906 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01907 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-72) (CXCL8) |
7-01908 |
CHI Scientific |
1mg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01912 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01913 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) |
7-01914 |
CHI Scientific |
1mg |
Ask for price |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA15789D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Gallus gallus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA08327D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA08329D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
CXCL8 Antibody, Biotin conjugated |
1-CSB-PA011671YD01DO |
Cusabio |
|
|
|
Description: A polyclonal antibody against CXCL8. Recognizes CXCL8 from dog. This antibody is Biotin conjugated. Tested in the following application: ELISA |
IL-8, CXCL8, Interleukin-8 (72 a.a.), human |
RC212-19A |
Bio Basic |
5ug |
EUR 125.26 |
|
IL-8, CXCL8, Interleukin-8 (77 a.a.), human |
RC212-19B |
Bio Basic |
5ug |
EUR 125.26 |
|
CXCL8 Recombinant Protein |
40-105-0005mg |
ProSci |
0.005 mg |
EUR 311.1 |
Description: CXCL8 (IL-8) is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. CXCL8 (IL-8) chemoattracts and activates neutrophils. Recombinant human CXCL8 (IL-8) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues. |
CXCL8 Recombinant Protein |
40-105-0025mg |
ProSci |
0.025 mg |
EUR 437.1 |
Description: CXCL8 (IL-8) is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. CXCL8 (IL-8) chemoattracts and activates neutrophils. Recombinant human CXCL8 (IL-8) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues. |
CXCL8 Recombinant Protein |
91-874 |
ProSci |
0.05 mg |
EUR 619.8 |
Description: Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. |
CXCL8 Chemi-Luminescent ELISA Kit (Human) (OKCD03689) |
OKCD03689 |
Aviva Systems Biology |
96 Wells |
EUR 1185.6 |
Description: Description of target: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.37 pg/mL |
Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein |
PROTP10145-4 |
BosterBio |
25ug |
EUR 380.4 |
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues. |
Recombinant Human IL-8 (77 a.a.) (CXCL8) Protein |
PROTP10145-5 |
BosterBio |
25ug |
EUR 380.4 |
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues. |
CXCL8 ELISA Kit (Human) : 48 Wells (OKAA00042-48W) |
OKAA00042-48W |
Aviva Systems Biology |
48 Wells |
EUR 573.6 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Method: Quantitative Sandwich ELISA;Sensitivity: 4 pg/ml |
CXCL8 ELISA Kit (Human) : 96 Wells (OKAA00042-96W) |
OKAA00042-96W |
Aviva Systems Biology |
96 Wells |
EUR 638.4 |
Description: Description of target: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.;Species reactivity: Human;Application: ELISA;Assay info: Assay Method: Quantitative Sandwich ELISA;Sensitivity: 4 pg/ml |
Recombinant (E.Coli) Human Interleuikin-8 (1-72) (CXCL8) |
RP-1000 |
Alpha Diagnostics |
5 ug |
EUR 196.8 |
Recombinant (E.Coli) Human Interleuikin-8 (1-77) (CXCL8) |
RP-1029 |
Alpha Diagnostics |
5 ug |
EUR 196.8 |
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx317929 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
abx200558-100ug |
Abbexa |
100 ug |
EUR 543.6 |
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx210112 |
Abbexa |
|
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx109944 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx110542 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx110581 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx113257 |
Abbexa |
|
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
abx034024-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Interleukin 8 / IL8 (CXCL8) Antibody |
abx034024-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx100968 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1412.40
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
20-abx001979 |
Abbexa |
-
EUR 493.20
-
EUR 126.00
-
EUR 710.40
-
EUR 218.40
|
- 100 ul
- 10 ul
- 200 ul
- 50 ul
|
|
Interleukin 8 / IL8 (CXCL8) Antibody |
abx011005-100ul |
Abbexa |
100 ul |
EUR 493.2 |
|
Recombinant Human Interleuikin-8 (1-77) (CXCL8) Pichia |
7-01915 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) Pichia |
7-01916 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Human Interleuikin-8 (1-77) (CXCL8) Pichia |
7-01917 |
CHI Scientific |
1mg |
Ask for price |
CXCL8 Polyclonal Antibody, HRP Conjugated |
A55396 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
CXCL8 Polyclonal Antibody, HRP Conjugated |
A51854 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
CXCL8 Polyclonal Antibody, HRP Conjugated |
A52035 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
CXCL8 Polyclonal Antibody, FITC Conjugated |
A55397 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
CXCL8 Polyclonal Antibody, FITC Conjugated |
A51855 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
CXCL8 Polyclonal Antibody, FITC Conjugated |
A52036 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
- In accordance with this, utilizing lysates of extremely purified (>90%) pores and skin mast cells, we might display that each TNF-alpha and IL-Eight mRNA and protein had been current in each unstimulated in addition to stimulated mast cells. In stark distinction to those outcomes, no important ranges of both IL-4, IL-5 or IL-13 had been detected, whatever the secretagogue used or the interval of stimulation.
- These outcomes present that human pores and skin mast cells are able to quickly secreting pro-inflammatory cytokines like TNF-alpha and IL-Eight following IgE-dependent activation and stimulation by the neuropeptide substance P, SCF and the essential polypeptide analogue compound 48/80. In distinction to different forms of human mast cells nonetheless, human pores and skin mast cells had been incapable of secreting IL-4, IL-5 or IL-13 in these settings.