Human UBE3A(Ubiquitin Protein Ligase E3A) ELISA Kit
To Order: [email protected]
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
20-abx153424 |
Abbexa |
-
EUR 8534.40
-
EUR 4550.40
-
EUR 1054.80
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Human Ubiquitin- protein ligase E3A, UBE3A ELISA KIT |
ELI-51307h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 600 |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 830.4 |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 626.4 |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 868.8 |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
SEB072Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5402.92 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ubiquitin Protein Ligase E3A (UBE3A) in tissue homogenates, cell lysates and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
SEB072Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 550.13 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ubiquitin Protein Ligase E3A (UBE3A) in tissue homogenates, cell lysates and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
SEB072Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 734.46 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ubiquitin Protein Ligase E3A (UBE3A) in tissue homogenates, cell lysates and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
SEB072Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2945.08 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ubiquitin Protein Ligase E3A (UBE3A) in tissue homogenates, cell lysates and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
4-SEB072Hu |
Cloud-Clone |
-
EUR 5463.60
-
EUR 2886.00
-
EUR 735.60
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Ubiquitin Protein Ligase E3A (UBE3A) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Hu-48T |
Reddot Biotech |
48T |
EUR 453.92 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Hu-96T |
Reddot Biotech |
96T |
EUR 648.38 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Hu-48T |
Reddot Biotech |
48T |
EUR 432.3 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
Human Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Hu-96T |
Reddot Biotech |
96T |
EUR 617.5 |
|
Description: tissue homogenates, cell lysates and other biological fluids. |
ELISA kit for Human UBE3A (Ubiquitin Protein Ligase E3A) |
E-EL-H1257 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Human UBE3A (Ubiquitin Protein Ligase E3A) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Human UBE3A (Ubiquitin Protein Ligase E3A) |
ELK1751 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of Ubiquitin Protein Ligase E3A from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Human UBE3A(Ubiquitin-protein ligase E3A) ELISA Kit |
EH2433 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml |
Human UBE3A/ Ubiquitin-protein ligase E3A ELISA Kit |
E2626Hu |
Sunlong |
1 Kit |
EUR 726 |
Pig Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx360992-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Sheep Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx364057-96tests |
Abbexa |
96 tests |
EUR 1111.2 |
|
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
DLR-UBE3A-Mu-48T |
DL Develop |
48T |
EUR 609.6 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ubiquitin Protein Ligase E3A (UBE3A) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
DLR-UBE3A-Mu-96T |
DL Develop |
96T |
EUR 793.2 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Ubiquitin Protein Ligase E3A (UBE3A) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Ubiquitin- protein ligase E3A, Ube3a ELISA KIT |
ELI-51308m |
Lifescience Market |
96 Tests |
EUR 1038 |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 613.2 |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 850.8 |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 640.8 |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 890.4 |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Mu-48T |
Reddot Biotech |
48T |
EUR 465.47 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RDR-UBE3A-Mu-96T |
Reddot Biotech |
96T |
EUR 664.97 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Mu-48T |
Reddot Biotech |
48T |
EUR 443.3 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
RD-UBE3A-Mu-96T |
Reddot Biotech |
96T |
EUR 633.3 |
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Rabbit Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx363033-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Monkey Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx359256-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Ubiquitin Protein Ligase E3A (UBE3A) Protein |
20-abx069596 |
Abbexa |
-
EUR 828.00
-
EUR 343.20
-
EUR 2532.00
-
EUR 978.00
-
EUR 594.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Chicken Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx356038-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Ubiquitin Protein Ligase E3A (UBE3A) CLIA Kit |
abx197883-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human Ubiquitin Protein Ligase E3A (UBE3A) CLIA Kit |
20-abx492385 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
CLIA kit for Human UBE3A (Ubiquitin Protein Ligase E3A) |
E-CL-H0816 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Human UBE3A (Ubiquitin Protein Ligase E3A) in samples from Serum, Plasma, Cell supernatant |
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
abx239189-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
abx239190-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
20-abx103075 |
Abbexa |
-
EUR 493.20
-
EUR 159.60
-
EUR 1378.80
-
EUR 678.00
-
EUR 376.80
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
20-abx175023 |
Abbexa |
|
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
20-abx116421 |
Abbexa |
|
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
20-abx333926 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
abx031558-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
abx031558-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
abx036313-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody |
20-abx006695 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Human Ubiquitin-protein ligase E3A (UBE3A) ELISA Kit |
abx572035-96tests |
Abbexa |
96 tests |
EUR 886.8 |
|
Guinea pig Ubiquitin Protein Ligase E3A (UBE3A) ELISA Kit |
abx357253-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Recombinant Ubiquitin Protein Ligase E3A (UBE3A) |
4-RPB072Hu01 |
Cloud-Clone |
-
EUR 588.79
-
EUR 280.80
-
EUR 1877.95
-
EUR 705.98
-
EUR 1291.97
-
EUR 469.20
-
EUR 4514.88
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Ubiquitin Protein Ligase E3A expressed in: E.coli |
ELISA kit for Human Ubiquitin-protein ligase E3A (UBE3A) |
KTE60098-48T |
Abbkine |
48T |
EUR 398.4 |
|
Description: Quantitative sandwich ELISA for measuring Human Ubiquitin-protein ligase E3A (UBE3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Ubiquitin-protein ligase E3A (UBE3A) |
KTE60098-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
Description: Quantitative sandwich ELISA for measuring Human Ubiquitin-protein ligase E3A (UBE3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Ubiquitin-protein ligase E3A (UBE3A) |
KTE60098-96T |
Abbkine |
96T |
EUR 646.8 |
|
Description: Quantitative sandwich ELISA for measuring Human Ubiquitin-protein ligase E3A (UBE3A) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Ubiquitin Protein Ligase E3A (UBE3A) Antibody (HRP) |
20-abx338236 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody (FITC) |
20-abx338237 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Ubiquitin Protein Ligase E3A (UBE3A) Antibody (Biotin) |
20-abx338238 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Mouse Ubiquitin-Protein Ligase E3A (UBE3A) ELISA Kit |
abx576754-96tests |
Abbexa |
96 tests |
EUR 886.8 |
|
Ubiquitin Protein Ligase E3A (UBE3A) Polyclonal Antibody (Human) |
4-PAB072Hu01 |
Cloud-Clone |
-
EUR 286.80
-
EUR 2869.20
-
EUR 717.60
-
EUR 358.80
-
EUR 253.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Ubiquitin Protein Ligase E3A (UBE3A) |
Ubiquitin protein ligase E3A (UBE3A) polyclonal antibody |
ABP-PAB-10492 |
Allele Biotech |
100 ug |
Ask for price |
|
Mouse Ubiquitin-protein ligase E3A (Ube3a) |
1-CSB-YP025488MO |
Cusabio |
-
EUR 703.20
-
EUR 358.80
-
EUR 2606.40
-
EUR 1080.00
-
EUR 1730.40
-
EUR 458.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Mouse Ubiquitin-protein ligase E3A(Ube3a),partial expressed in Yeast |
Mouse Ubiquitin-protein ligase E3A (Ube3a) |
1-CSB-EP025488MO |
Cusabio |
-
EUR 733.20
-
EUR 370.80
-
EUR 2192.40
-
EUR 1126.80
-
EUR 1461.60
-
EUR 476.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Mouse Ubiquitin-protein ligase E3A(Ube3a),partial expressed in E.coli |
Mouse Ubiquitin-protein ligase E3A (Ube3a) |
1-CSB-MP025488MO |
Cusabio |
-
EUR 351.60
-
EUR 1155.60
-
EUR 490.80
-
EUR 860.40
|
|
|
Description: Recombinant Mouse Ubiquitin-protein ligase E3A(Ube3a) ,partial expressed in Mammalian cell |
Ubiquitin Protein Ligase E3A (UBE3A) Polyclonal Antibody (Human), PE |
4-PAB072Hu01-PE |
Cloud-Clone |
-
EUR 344.40
-
EUR 3012.00
-
EUR 860.40
-
EUR 430.80
-
EUR 230.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Ubiquitin Protein Ligase E3A (UBE3A). This antibody is labeled with PE. |
Ubiquitin Protein Ligase E3A (UBE3A) Polyclonal Antibody (Human), APC |
4-PAB072Hu01-APC |
Cloud-Clone |
-
EUR 399.60
-
EUR 3735.60
-
EUR 1046.40
-
EUR 507.60
-
EUR 258.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Ubiquitin Protein Ligase E3A (UBE3A). This antibody is labeled with APC. |
Ubiquitin Protein Ligase E3A (UBE3A) Polyclonal Antibody (Human), Cy3 |
4-PAB072Hu01-Cy3 |
Cloud-Clone |
-
EUR 483.60
-
EUR 4930.80
-
EUR 1345.20
-
EUR 627.60
-
EUR 294.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Ubiquitin Protein Ligase E3A (UBE3A). This antibody is labeled with Cy3. |
Ubiquitin Protein Ligase E3A (UBE3A) Polyclonal Antibody (Human), HRP |
4-PAB072Hu01-HRP |
Cloud-Clone |
-
EUR 366.00
-
EUR 3256.80
-
EUR 926.40
-
EUR 459.60
-
EUR 243.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Ubiquitin Protein Ligase E3A (UBE3A). This antibody is labeled with HRP. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
F54766-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: UBE3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. It appears that only unmodified E6-AP molecules can bind efficiently to p53 in the presence of the HPV E6 oncoprotein. UBE3A binds UBQLN1 and UBQLN2. Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove. UBE3A contains 1 HECT-type E3 ubiquitin-protein ligase domain. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
F54766-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: UBE3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. It appears that only unmodified E6-AP molecules can bind efficiently to p53 in the presence of the HPV E6 oncoprotein. UBE3A binds UBQLN1 and UBQLN2. Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove. UBE3A contains 1 HECT-type E3 ubiquitin-protein ligase domain. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
RQ6275 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
RQ6276 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
V9248-100UG |
NSJ Bioreagents |
100ug |
EUR 349.3 |
Description: E6-associating protein (E6-AP), also designated ubiquitin protein ligase E3A (UBE3A), is a component of the ubiquitin-mediated proteolytic pathway that selectively targets proteins for degradation by the 26S Proteasome. Ubiquitin(Ub) is directly conjugated to protein substrates by the transfer of Ub from anE2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such asE6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A.Previous studies have indicated that E6-AP associates with the human papilloma virus E6 oncogene, which forms a complex with p53 and there by potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation. |
Ubiquitin-protein ligase E3A Antibody / UBE3A |
V9248-20UG |
NSJ Bioreagents |
20ug |
EUR 153.3 |
Description: E6-associating protein (E6-AP), also designated ubiquitin protein ligase E3A (UBE3A), is a component of the ubiquitin-mediated proteolytic pathway that selectively targets proteins for degradation by the 26S Proteasome. Ubiquitin(Ub) is directly conjugated to protein substrates by the transfer of Ub from anE2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such asE6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A.Previous studies have indicated that E6-AP associates with the human papilloma virus E6 oncogene, which forms a complex with p53 and there by potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation. |
Human UBE3A(Ubiquitin Protein Ligase E3A) ELISA Kit