Anti-Podoplanin antibody
- Antibody-drug conjugates (ADCs), which encompass a monoclonal antibody (mAb), a linker, and a payload, can ship a drug to most cancers tissues. We beforehand produced an anti-dog podoplanin (dPDPN) mAb, PMab-38, which reacts with dPDPN-expressing canine melanomas and squamous cell carcinomas (SCCs), however not with dPDPN-expressing canine sort I alveolar cells or lymphatic endothelial cells, indicating that PMab-38 possesses most cancers specificity.
- On this examine, we developed an ADC, P38B-DM1, utilizing the mouse-canine chimeric anti-dPDPN antibody, P38B because the antibody, a peptide linker, and emtansine because the payload utilizing the chemical conjugation by affinity peptide (CCAP) methodology.
- We investigated its cytotoxicity towards dPDPN–overexpressed Chinese language hamster ovary (CHO/dPDPN) cells in vitro and its antitumor exercise utilizing a mouse xenograft mannequin of CHO/dPDPN cells. P38B-DM1 confirmed cytotoxicity to CHO/dPDPN cells in a dose-dependent method in vitro.
Rabbit Polyclonal antibody Anti-CRBN
- Moreover, P38B-DM1 exhibited larger antitumor exercise than P38B within the mouse xenograft mannequin. These outcomes counsel that P38B-DM1, developed utilizing the CCAP methodology, is helpful for antibody remedy towards dPDPN-expressing canine SCCs and melanomas.
Anti-Podoplanin/gp36/PDPN Antibody |
- Podoplanin (PDPN) is a kind I transmembrane intently glycosylated sialoglycoprotein that is expressed in common tissues much like pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is said to hematogenous metastasis by way of interactions with the C-type lectin-like receptor 2 (CLEC-2). Beforehand, we’ve now reported the occasion of a mouse monoclonal antibody (mAb), PMab-38 (IgG1, kappa) in the direction of canine PDPN (dPDPN).
Mouse anti Podoplanin-Biotin (human) |
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101-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Hamster anti Podoplanin-Biotin (mouse) |
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103-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Anti-Mouse Podoplanin Antibody |
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103-M552 | ReliaTech | 100 µg | EUR 399 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Anti-Mouse Podoplanin Antibody |
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103-PA40 | ReliaTech | 200 µg | EUR 204.75 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Anti-Mouse Podoplanin Antibody |
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103-PA40S | ReliaTech | 100 µg | EUR 126 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Mouse Podoplanin ELISA kit |
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E01A24381 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Mouse Podoplanin ELISA kit |
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E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
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E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
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E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA Kit |
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IMSPDPNKT | Innovative research | each | EUR 752 |
Description: Mouse Podoplanin ELISA Kit |
anti- Podoplanin antibody |
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FNab06598 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Podoplanin |
anti- Podoplanin antibody |
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FNab06599 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Podoplanin |
Mouse Monoclonal anti-Rat Podoplanin Antibody |
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xAP-0897 | Angio Proteomie | 100ug | EUR 280 |
Mouse Podoplanin (PDPN) Protein |
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20-abx650139 | Abbexa |
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Mouse Podoplanin (PDPN) Protein |
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abx694266-10nmol | Abbexa | 10 nmol | EUR 700 |
Mouse Podoplanin (PDPN) Protein |
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abx694266-5nmol | Abbexa | 5 nmol | EUR 462.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-100g | Abbexa | 100 µg | EUR 537.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-10g | Abbexa | 10 µg | EUR 212.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-50g | Abbexa | 50 µg | EUR 375 |
Mouse Monoclonal Podoplanin Antibody |
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TA327727 | Origene Technologies GmbH | 1 ml | Ask for price |
Mouse Podoplanin (PDPN) CLIA Kit |
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20-abx493858 | Abbexa |
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Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu | DL Develop | 96T | EUR 475 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-96T | DL Develop | 96T | EUR 825.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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EK8596 | SAB | 96Т | EUR 799 |
Mouse Podoplanin, Pdpn ELISA KIT |
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ELI-06723m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-48T | Biomatik Corporation | 48T | EUR 389.62 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-5x96T | Biomatik Corporation | 5x96T | EUR 2643.85 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-96T | Biomatik Corporation | 96T | EUR 556.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-48T | Biomatik Corporation | 48T | EUR 571.55 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-5x96T | Biomatik Corporation | 5x96T | EUR 3878.38 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-96T | Biomatik Corporation | 96T | EUR 816.5 |
Mouse Podoplanin (PDPN) ELISA Kit |
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DL-PDPN-Mu | DL Develop | 96T | EUR 453 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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abx571749-96tests | Abbexa | 96 tests | EUR 943.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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AE28131MO-48Tests | Abebio | 48 Tests | EUR 325 |
Description: Mouse (Mus musculus) |
Mouse Podoplanin (PDPN) ELISA Kit |
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AE28131MO-96Tests | Abebio | 96 Tests | EUR 610 |
Description: Mouse (Mus musculus) |
Mouse Podoplanin (PDPN) ELISA Kit |
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20-abx154564 | Abbexa |
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Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 464.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 663.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 888 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RK13459 | Abclonal | 96T | EUR 280 |
Mouse Podoplanin(PDPN)ELISA kit |
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QY-E21215 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5834.88 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 585.7 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 785.28 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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SEC719Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3173.76 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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4-SEC719Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
- PMab-38 was found to strongly react with canine squamous cell carcinomas (SCCs) and melanomas; nonetheless, it confirmed no response with lymphatic endothelial cells. Simply recently, we’ve now developed and produced the mouse-canine mAb of subclass B, P38B that confirmed antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity in the direction of Chinese language language hamster ovary (CHO)/dPDPN cells. Throughout the present analysis, we investigated the antitumor train using mouse xenograft model.
- To induce ADCC train by P38B, canine mononuclear cells have been injected surrounding the tumors in a xenograft model. It was demonstrated that P38B exerted antitumor train in the direction of the mouse xenograft model using CHO/dPDPN. These outcomes suggest that P38B is useful for antibody treatment in the direction of dPDPN-expressing canine SCCs and melanomas.
Syrian Hamster Monoclonal anti-Mouse Podoplanin Antibody |
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xAP-0811 | Angio Proteomie | 100ug | EUR 280 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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CABT-L4294-1mg | Creative Diagnostics | 1 mg | EUR 1076.4 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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CABT-L4294-5mg | Creative Diagnostics | 5 mg | EUR 2886 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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CABT-L4294 | Creative Diagnostics | 1 mg; 5 mg | Ask for price |
Description: Syrian Hamster |
Golden Syrian Hamster Monoclonal Podoplanin Antibody (8.1.1) |
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TA336668 | Origene Technologies GmbH | 100 µl | Ask for price |
Mouse anti Podoplanin (human) |
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101-M40 | Angio Proteomie | 100ug | EUR 297.6 |
Mouse anti Podoplanin-Biotin (human) |
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101-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Anti-Mouse Podoplanin Antibody |
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103-M552 | ReliaTech | 100 µg | EUR 399 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Anti-Mouse Podoplanin Antibody |
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103-PA40 | ReliaTech | 200 µg | EUR 204.75 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Anti-Mouse Podoplanin Antibody |
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103-PA40S | ReliaTech | 100 µg | EUR 126 |
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. |
Mouse Podoplanin ELISA kit |
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E01A24381 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Mouse Podoplanin ELISA kit |
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E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
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E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
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E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA Kit |
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IMSPDPNKT | Innovative research | each | EUR 752 |
Description: Mouse Podoplanin ELISA Kit |
anti- Podoplanin antibody |
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FNab06598 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Podoplanin |
anti- Podoplanin antibody |
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FNab06599 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Podoplanin |
Mouse Monoclonal anti-Rat Podoplanin Antibody |
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xAP-0897 | Angio Proteomie | 100ug | EUR 280 |
Mouse Podoplanin (PDPN) Protein |
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20-abx650139 | Abbexa |
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Mouse Podoplanin (PDPN) Protein |
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abx694266-10nmol | Abbexa | 10 nmol | EUR 700 |
Mouse Podoplanin (PDPN) Protein |
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abx694266-5nmol | Abbexa | 5 nmol | EUR 462.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-100g | Abbexa | 100 µg | EUR 537.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-10g | Abbexa | 10 µg | EUR 212.5 |
Mouse Podoplanin (PDPN) Protein |
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abx650139-50g | Abbexa | 50 µg | EUR 375 |
Mouse Monoclonal Podoplanin Antibody |
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TA327727 | Origene Technologies GmbH | 1 ml | Ask for price |
Mouse Podoplanin (PDPN) CLIA Kit |
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20-abx493858 | Abbexa |
|
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Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu | DL Develop | 96T | EUR 475 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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DLR-PDPN-Mu-96T | DL Develop | 96T | EUR 825.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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EK8596 | SAB | 96Т | EUR 799 |
Mouse Podoplanin, Pdpn ELISA KIT |
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ELI-06723m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-48T | Biomatik Corporation | 48T | EUR 389.62 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-5x96T | Biomatik Corporation | 5x96T | EUR 2643.85 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKN47838-96T | Biomatik Corporation | 96T | EUR 556.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-48T | Biomatik Corporation | 48T | EUR 571.55 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-5x96T | Biomatik Corporation | 5x96T | EUR 3878.38 |
Mouse Podoplanin (PDPN) ELISA Kit |
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EKU06727-96T | Biomatik Corporation | 96T | EUR 816.5 |
Mouse Podoplanin (PDPN) ELISA Kit |
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DL-PDPN-Mu | DL Develop | 96T | EUR 453 |
Description: tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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abx571749-96tests | Abbexa | 96 tests | EUR 943.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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AE28131MO-48Tests | Abebio | 48 Tests | EUR 325 |
Description: Mouse (Mus musculus) |
Mouse Podoplanin (PDPN) ELISA Kit |
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AE28131MO-96Tests | Abebio | 96 Tests | EUR 610 |
Description: Mouse (Mus musculus) |
Mouse Podoplanin (PDPN) ELISA Kit |
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20-abx154564 | Abbexa |
|
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Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48T | Reddot Biotech | 48T | EUR 464.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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RD-PDPN-Mu-96T | Reddot Biotech | 96T | EUR 663.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Anti-Podoplanin Rabbit Monoclonal Antibody |
- Podoplanin is expressed in a lot of cancers, along with oral cancers and thoughts tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in most cancers metastasis and tumor malignancy. We beforehand established many monoclonal antibodies (mAbs) in the direction of human podoplanin using the cancer-specific mAb (CasMab) experience. LpMab-23 (IgG1, kappa), one in every of many mouse anti-podoplanin mAbs, was confirmed to be a CasMab.
- Nonetheless, we’ve no longer confirmed the usefulness of LpMab-23 for antibody treatment in the direction of podoplanin-expressing cancers. On this analysis, we first determined the minimal epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, notably Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a important epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether or not or not chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor train.
Anti-D2-40 Podoplanin antibody
- In stream cytometry, chLpMab-23 confirmed extreme sensitivity in the direction of a podoplanin-expressing glioblastoma cell line, LN319, and an oral most cancers cell line, HSC-2. chLpMab-23 moreover confirmed ADCC train in the direction of podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft fashions with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor train using human pure killer cells, indicating that chLpMab-23 could very nicely be useful for antibody treatment in the direction of podoplanin-expressing cancers.