Anti-Podoplanin antibody
- Antibody-drug conjugates (ADCs), which encompass a monoclonal antibody (mAb), a linker, and a payload, can ship a drug to most cancers tissues. We beforehand produced an anti-dog podoplanin (dPDPN) mAb, PMab-38, which reacts with dPDPN-expressing canine melanomas and squamous cell carcinomas (SCCs), however not with dPDPN-expressing canine sort I alveolar cells or lymphatic endothelial cells, indicating that PMab-38 possesses most cancers specificity.
- On this examine, we developed an ADC, P38B-DM1, utilizing the mouse-canine chimeric anti-dPDPN antibody, P38B because the antibody, a peptide linker, and emtansine because the payload utilizing the chemical conjugation by affinity peptide (CCAP) methodology.
- We investigated its cytotoxicity towards dPDPN–overexpressed Chinese language hamster ovary (CHO/dPDPN) cells in vitro and its antitumor exercise utilizing a mouse xenograft mannequin of CHO/dPDPN cells. P38B-DM1 confirmed cytotoxicity to CHO/dPDPN cells in a dose-dependent method in vitro.
Rabbit Polyclonal antibody Anti-CRBN
- Moreover, P38B-DM1 exhibited larger antitumor exercise than P38B within the mouse xenograft mannequin. These outcomes counsel that P38B-DM1, developed utilizing the CCAP methodology, is helpful for antibody remedy towards dPDPN-expressing canine SCCs and melanomas.
Anti-Podoplanin/gp36/PDPN Antibody |
- Podoplanin (PDPN) is a kind I transmembrane intently glycosylated sialoglycoprotein that is expressed in common tissues much like pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is said to hematogenous metastasis by way of interactions with the C-type lectin-like receptor 2 (CLEC-2). Beforehand, we’ve now reported the occasion of a mouse monoclonal antibody (mAb), PMab-38 (IgG1, kappa) in the direction of canine PDPN (dPDPN).
MOUSE ANTI HUMAN PODOPLANIN |
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| MBS212743-5x01mg | MyBiosource | 5x0.1mg | EUR 1840 |
Mouse Anti Human Podoplanin |
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| MBS140296-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Podoplanin |
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| MBS140296-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Podoplanin |
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| MBS140296-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Podoplanin |
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| MBS140296-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
Mouse Anti-Rat Podoplanin |
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| MBS690143-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Rat Podoplanin |
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| MBS690143-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Hamster anti Podoplanin (mouse) |
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| 103-M40 | Angio Proteomie | 100ug | EUR 297.6 |
Mouse Anti-Human Podoplanin |
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| MBS690117-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
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| MBS690117-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
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| MBS690586-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS690586-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690680-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
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| MBS690680-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
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| MBS690759-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS690759-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690992-005mg | MyBiosource | 0.05mg | EUR 430 |
Mouse Anti-Human Podoplanin |
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| MBS690992-5x005mg | MyBiosource | 5x0.05mg | EUR 1645 |
Mouse Anti-Human Podoplanin |
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| MBS692357-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS692357-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS692358-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS692358-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse anti Podoplanin-Biotin (human) |
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| 101-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Hamster anti Podoplanin-Biotin (mouse) |
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| 103-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Podoplanin Mouse mAb |
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| A18776 | Abclonal | 100μL | EUR 719.13 |
Podoplanin Mouse mAb |
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| E47M34236 | EnoGene | 100ul | EUR 295 |
Mouse Podoplanin, soluble |
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| MBS691731-0005mg | MyBiosource | 0.005mg | EUR 250 |
Mouse Podoplanin, soluble |
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| MBS691731-5x0005mg | MyBiosource | 5x0.005mg | EUR 835 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
Anti-Human/Mouse PDPN/Podoplanin Antibody |
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| MBS1569238-01mg | MyBiosource | 0.1mg | EUR 405 |
Anti-Human/Mouse PDPN/Podoplanin Antibody |
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| MBS1569238-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
Recombinant Mouse Podoplanin |
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| MBS7610672-005mg | MyBiosource | 0.05mg | EUR 345 |
Recombinant Mouse Podoplanin |
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| MBS7610672-02mg | MyBiosource | 0.2mg | EUR 635 |
Recombinant Mouse Podoplanin |
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| MBS7610672-1mg | MyBiosource | 1mg | EUR 1800 |
Recombinant Mouse Podoplanin |
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| MBS7610672-5x1mg | MyBiosource | 5x1mg | EUR 6955 |
Mouse Monoclonal anti-Rat Podoplanin Antibody |
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| xAP-0897 | Angio Proteomie | 100ug | EUR 280 |
Mouse Podoplanin ELISA kit |
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| E01A24381 | BlueGene | 96T | EUR 700 |
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Description: ELISA |
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Mouse Podoplanin ELISA kit |
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| E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse Podoplanin ELISA kit |
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| E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
Mouse Podoplanin ELISA Kit |
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| IMSPDPNKT | Innovative research | each | EUR 752 |
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Description: Mouse Podoplanin ELISA Kit |
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Mouse Podoplanin ELISA Kit |
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| MBS2884556-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4080 |
Mouse Podoplanin ELISA Kit |
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| MBS2884556-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
- PMab-38 was found to strongly react with canine squamous cell carcinomas (SCCs) and melanomas; nonetheless, it confirmed no response with lymphatic endothelial cells. Simply recently, we’ve now developed and produced the mouse-canine mAb of subclass B, P38B that confirmed antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity in the direction of Chinese language language hamster ovary (CHO)/dPDPN cells. Throughout the present analysis, we investigated the antitumor train using mouse xenograft model.
- To induce ADCC train by P38B, canine mononuclear cells have been injected surrounding the tumors in a xenograft model. It was demonstrated that P38B exerted antitumor train in the direction of the mouse xenograft model using CHO/dPDPN. These outcomes suggest that P38B is useful for antibody treatment in the direction of dPDPN-expressing canine SCCs and melanomas.
Hamster Anti-Mouse Podoplanin |
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| MBS690790-005mg | MyBiosource | 0.05mg | EUR 430 |
Hamster Anti-Mouse Podoplanin |
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| MBS690790-5x005mg | MyBiosource | 5x0.05mg | EUR 1645 |
Hamster Monoclonal anti-mouse Podoplanin |
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| mAP-0062 | Angio Proteomie | 100ug | EUR 250 |
Podoplanin Hamster, Antibody |
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| GWB-F6A4B3 | GenWay Biotech | 0.1 mg | Ask for price |
Hamster Podoplanin ELISA Kit |
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| MBS015508-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Hamster Podoplanin ELISA Kit |
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| MBS015508-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Hamster Podoplanin ELISA Kit |
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| MBS015508-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Hamster Podoplanin ELISA Kit |
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| MBS015508-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Syrian Hamster Monoclonal anti-Mouse Podoplanin Antibody |
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| xAP-0811 | Angio Proteomie | 100ug | EUR 280 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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| CABT-L4294 | Creative Diagnostics | 1 mg; 5 mg | Ask for price |
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Description: Syrian Hamster |
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Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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| CABT-L4294-1mg | Creative Diagnostics | 1 mg | EUR 1076.4 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
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| CABT-L4294-5mg | Creative Diagnostics | 5 mg | EUR 2886 |
Golden Syrian Hamster Monoclonal Podoplanin Antibody (8.1.1) |
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| TA336668 | Origene Technologies GmbH | 100 µl | Ask for price |
Mouse anti Podoplanin (human) |
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| 101-M40 | Angio Proteomie | 100ug | EUR 297.6 |
Mouse Anti Human Podoplanin |
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| MBS140296-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Podoplanin |
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| MBS140296-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Podoplanin |
|||
| MBS140296-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Podoplanin |
|||
| MBS140296-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
MOUSE ANTI HUMAN PODOPLANIN |
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| MBS212743-01mg | MyBiosource | 0.1mg | EUR 450 |
MOUSE ANTI HUMAN PODOPLANIN |
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| MBS212743-5x01mg | MyBiosource | 5x0.1mg | EUR 1840 |
Mouse Anti-Rat Podoplanin |
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| MBS690143-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Rat Podoplanin |
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| MBS690143-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690117-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
|||
| MBS690117-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
|||
| MBS690586-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
|||
| MBS690586-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
|||
| MBS690680-0025mg | MyBiosource | 0.025mg | EUR 310 |
Mouse Anti-Human Podoplanin |
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| MBS690680-5x0025mg | MyBiosource | 5x0.025mg | EUR 1110 |
Mouse Anti-Human Podoplanin |
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| MBS690759-01mg | MyBiosource | 0.1mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS690759-5x01mg | MyBiosource | 5x0.1mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
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| MBS690992-005mg | MyBiosource | 0.05mg | EUR 430 |
Mouse Anti-Human Podoplanin |
|||
| MBS690992-5x005mg | MyBiosource | 5x0.05mg | EUR 1645 |
Mouse Anti-Human Podoplanin |
|||
| MBS692357-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
|||
| MBS692357-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse Anti-Human Podoplanin |
|||
| MBS692358-005mg | MyBiosource | 0.05mg | EUR 450 |
Mouse Anti-Human Podoplanin |
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| MBS692358-5x005mg | MyBiosource | 5x0.05mg | EUR 1725 |
Mouse anti Podoplanin-Biotin (human) |
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| 101-MBi40 | Angio Proteomie | 50ug | EUR 297.6 |
Podoplanin Mouse mAb |
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| A18776 | Abclonal | 100μL | EUR 719.13 |
Podoplanin Mouse mAb |
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| E47M34236 | EnoGene | 100ul | EUR 295 |
Mouse Podoplanin, soluble |
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| MBS691731-0005mg | MyBiosource | 0.005mg | EUR 250 |
Mouse Podoplanin, soluble |
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| MBS691731-5x0005mg | MyBiosource | 5x0.005mg | EUR 835 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-0005mg | MyBiosource | 0.005mg | EUR 240 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-002mg | MyBiosource | 0.02mg | EUR 310 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-01mg | MyBiosource | 0.1mg | EUR 610 |
Mouse Anti Human Podoplanin clone P56F7AT |
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| MBS146676-5x01mg | MyBiosource | 5x0.1mg | EUR 2405 |
Anti-Podoplanin Rabbit Monoclonal Antibody |
- Podoplanin is expressed in a lot of cancers, along with oral cancers and thoughts tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in most cancers metastasis and tumor malignancy. We beforehand established many monoclonal antibodies (mAbs) in the direction of human podoplanin using the cancer-specific mAb (CasMab) experience. LpMab-23 (IgG1, kappa), one in every of many mouse anti-podoplanin mAbs, was confirmed to be a CasMab.
- Nonetheless, we’ve no longer confirmed the usefulness of LpMab-23 for antibody treatment in the direction of podoplanin-expressing cancers. On this analysis, we first determined the minimal epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, notably Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a important epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether or not or not chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor train.
Anti-D2-40 Podoplanin antibody
- In stream cytometry, chLpMab-23 confirmed extreme sensitivity in the direction of a podoplanin-expressing glioblastoma cell line, LN319, and an oral most cancers cell line, HSC-2. chLpMab-23 moreover confirmed ADCC train in the direction of podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft fashions with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor train using human pure killer cells, indicating that chLpMab-23 could very nicely be useful for antibody treatment in the direction of podoplanin-expressing cancers.