Anti-Podoplanin antibody
- Antibody-drug conjugates (ADCs), which encompass a monoclonal antibody (mAb), a linker, and a payload, can ship a drug to most cancers tissues. We beforehand produced an anti-dog podoplanin (dPDPN) mAb, PMab-38, which reacts with dPDPN-expressing canine melanomas and squamous cell carcinomas (SCCs), however not with dPDPN-expressing canine sort I alveolar cells or lymphatic endothelial cells, indicating that PMab-38 possesses most cancers specificity.
- On this examine, we developed an ADC, P38B-DM1, utilizing the mouse-canine chimeric anti-dPDPN antibody, P38B because the antibody, a peptide linker, and emtansine because the payload utilizing the chemical conjugation by affinity peptide (CCAP) methodology.
- We investigated its cytotoxicity towards dPDPN–overexpressed Chinese language hamster ovary (CHO/dPDPN) cells in vitro and its antitumor exercise utilizing a mouse xenograft mannequin of CHO/dPDPN cells. P38B-DM1 confirmed cytotoxicity to CHO/dPDPN cells in a dose-dependent method in vitro.
Rabbit Polyclonal antibody Anti-CRBN
- Moreover, P38B-DM1 exhibited larger antitumor exercise than P38B within the mouse xenograft mannequin. These outcomes counsel that P38B-DM1, developed utilizing the CCAP methodology, is helpful for antibody remedy towards dPDPN-expressing canine SCCs and melanomas.
Anti-Podoplanin/gp36/PDPN Antibody |
- Podoplanin (PDPN) is a kind I transmembrane intently glycosylated sialoglycoprotein that is expressed in common tissues much like pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is said to hematogenous metastasis by way of interactions with the C-type lectin-like receptor 2 (CLEC-2). Beforehand, we’ve now reported the occasion of a mouse monoclonal antibody (mAb), PMab-38 (IgG1, kappa) in the direction of canine PDPN (dPDPN).
Anti-Podoplanin antibody |
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| PAab06599 | Lifescience Market | 100 ug | EUR 494.4 |
anti- Podoplanin antibody |
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| FNab06598 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Podoplanin |
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anti- Podoplanin antibody |
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| FNab06599 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against Podoplanin |
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Anti-Podoplanin antibody |
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| STJ180226 | St John's Laboratory | 0.1 ml | EUR 319.2 |
Anti-Podoplanin antibody |
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| STJ180283 | St John's Laboratory | 0.1 ml | EUR 267.6 |
Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Podoplanin |
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| MO47016 | Neuromics | 100 ul | EUR 418.8 |
Mouse Podoplanin (PDPN) Protein |
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| 20-abx650139 | Abbexa |
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Mouse Podoplanin ELISA kit |
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| E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Anti-Podoplanin/gp36/PDPN Antibody |
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| A01124 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin Rabbit Monoclonal Antibody |
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| M01124-1 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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Anti-Podoplanin Rabbit Monoclonal Antibody |
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| M01124-2 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human. |
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Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1411 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1674 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1675 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-D2-40 Podoplanin antibody |
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| STJ16100360 | St John's Laboratory | 1 mL | EUR 1482 |
Anti-D2-40/Podoplanin antibody |
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| STJ190048 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1) |
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Podoplanin antibody |
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| 70R-11540 | Fitzgerald | 100 ug | EUR 632.4 |
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Description: Rabbit polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-50819 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-13952 | Fitzgerald | 100 ug | EUR 366 |
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Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
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Podoplanin Antibody |
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| 49474-100ul | SAB | 100ul | EUR 399.6 |
Podoplanin Antibody |
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| 49474-50ul | SAB | 50ul | EUR 286.8 |
Podoplanin antibody |
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| 10R-7662 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-7663 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Hamster monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-7664 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-P133a | Fitzgerald | 100 ug | EUR 608.4 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-P155a | Fitzgerald | 100 ug | EUR 651.6 |
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Description: Hamster monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-PR007 | Fitzgerald | 100 ug | EUR 506.4 |
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Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-6816 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN |
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Podoplanin antibody |
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| 70R-6817 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN |
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Podoplanin Antibody |
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| DF12456 | Affbiotech | 200ul | EUR 420 |
Podoplanin Antibody |
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| P1051-01m | SAB | 0.1m | EUR 250.8 |
Podoplanin Antibody |
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| P1051-1ml | SAB | 1ml | EUR 1129.2 |
Podoplanin Antibody |
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| R33852-100UG | NSJ Bioreagents | 100 ug | EUR 399 |
Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761 |
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| CABT-L2919-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| 20-abx154564 | Abbexa |
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Mouse Podoplanin (PDPN) CLIA Kit |
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| 20-abx493858 | Abbexa |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| abx571749-96tests | Abbexa | 96 tests | EUR 943.2 |
Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-10ug | Novoprotein | 10ug | EUR 157.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-500ug | Novoprotein | 500ug | EUR 1399.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-50ug | Novoprotein | 50ug | EUR 327.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
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- PMab-38 was found to strongly react with canine squamous cell carcinomas (SCCs) and melanomas; nonetheless, it confirmed no response with lymphatic endothelial cells. Simply recently, we’ve now developed and produced the mouse-canine mAb of subclass B, P38B that confirmed antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity in the direction of Chinese language language hamster ovary (CHO)/dPDPN cells. Throughout the present analysis, we investigated the antitumor train using mouse xenograft model.
- To induce ADCC train by P38B, canine mononuclear cells have been injected surrounding the tumors in a xenograft model. It was demonstrated that P38B exerted antitumor train in the direction of the mouse xenograft model using CHO/dPDPN. These outcomes suggest that P38B is useful for antibody treatment in the direction of dPDPN-expressing canine SCCs and melanomas.
Anti-Podoplanin antibody |
|||
| PAab06599 | Lifescience Market | 100 ug | EUR 494.4 |
anti- Podoplanin antibody |
|||
| FNab06598 | FN Test | 100µg | EUR 702 |
|
Description: Antibody raised against Podoplanin |
|||
anti- Podoplanin antibody |
|||
| FNab06599 | FN Test | 100µg | EUR 702 |
|
Description: Antibody raised against Podoplanin |
|||
Anti-Podoplanin antibody |
|||
| STJ180226 | St John's Laboratory | 0.1 ml | EUR 319.2 |
Anti-Podoplanin antibody |
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| STJ180283 | St John's Laboratory | 0.1 ml | EUR 267.6 |
Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
Hamster Mono Anti-Mouse CD3e IgG (Hamster IgG) |
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| MCD003E-M | Alpha Diagnostics | 100 Tests | EUR 578.4 |
Hamster Mono Anti-Mouse CD3z IgG (Hamster IgG) |
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| MCD003Z-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Podoplanin |
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| MO47016 | Neuromics | 100 ul | EUR 418.8 |
Hamster Mono Anti-Mouse CD25 , Pur. Low Endotoxin (Hamster IgG) |
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| MCD027-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Mouse Podoplanin (PDPN) Protein |
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| 20-abx650139 | Abbexa |
|
|
Mouse Podoplanin ELISA kit |
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| E03P0082-192T | BlueGene | 192 tests | EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|||
Mouse Podoplanin ELISA kit |
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| E03P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Podoplanin ELISA kit |
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| E03P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Anti-Podoplanin/gp36/PDPN Antibody |
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| A01124 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin Rabbit Monoclonal Antibody |
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| M01124-1 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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Anti-Podoplanin Rabbit Monoclonal Antibody |
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| M01124-2 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human. |
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Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1411 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1674 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Podoplanin/gp36/PDPN Antibody |
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| PA1675 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-D2-40 Podoplanin antibody |
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| STJ16100360 | St John's Laboratory | 1 mL | EUR 1482 |
Anti-D2-40/Podoplanin antibody |
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| STJ190048 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1) |
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Hamster Anti Mouse Cd29 Monoclonal Antibody |
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| CABT-45874HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Cd152 Monoclonal Antibody |
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| CABT-47114HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Cd154 Monoclonal Antibody |
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| CABT-47157HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Cd178 Monoclonal Antibody |
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| CABT-47221HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Cd195 Monoclonal Antibody |
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| CABT-47249HM | Creative Diagnostics | 0.25 mg | EUR 795.6 |
Hamster Anti Mouse Cd28 Monoclonal Antibody |
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| CABT-48079HM | Creative Diagnostics | 0.2 mg | EUR 795.6 |
Hamster Anti Mouse Cd81 Monoclonal Antibody |
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| CABT-48269HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Cd339 Monoclonal Antibody |
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| CABT-49800HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Jagged2 Monoclonal Antibody |
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| CABT-49812HM | Creative Diagnostics | 0.1 mg | EUR 546 |
Hamster Anti Mouse Bim Monoclonal Antibody |
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| CABT-50130HM | Creative Diagnostics | 0.1 mg | EUR 670.8 |
Hamster Anti Mouse Cd278 Monoclonal Antibody |
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| CABT-51735HM | Creative Diagnostics | 0.25 mg | EUR 795.6 |
Hamster Anti Mouse Cd27 Monoclonal Antibody |
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| CABT-54688HM | Creative Diagnostics | 0.25 mg | EUR 795.6 |
mAb hamster anti-mouse IL-9 |
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| CT327 | U-CyTech | 0.5 mg | EUR 312 |
Mouse Anti Hamster Marco Monoclonal Antibody |
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| DMABT-47716MH | Creative Diagnostics | 0.25 mg | EUR 889.2 |
Hamster Mono Anti-Mouse CD3e, Biotin (Clone 145-2C11) (hamster IgG) |
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| MCD003E-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
Hamster Mono Anti-Mouse CD3e, FITC (Clone 145-2C11) (hamster IgG) |
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| MCD003E-F | Alpha Diagnostics | 100 tests | EUR 562.8 |
Hamster Mono Anti-Mouse CD3z, Biotin (Clone H146-968) (hamster IgG) |
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| MCD003Z-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
Hamster Mono Anti-Mouse CD3z, FITC (Clone H146-968) (hamster IgG) |
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| MCD003Z-F | Alpha Diagnostics | 100 tests | EUR 562.8 |
Hamster Mono Anti-Mouse CD3z, PE (Clone H146-968) (hamster IgG) |
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| MCD003Z-PE | Alpha Diagnostics | 100 tests | EUR 562.8 |
Podoplanin antibody |
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| 70R-11540 | Fitzgerald | 100 ug | EUR 632.4 |
|
Description: Rabbit polyclonal Podoplanin antibody |
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Podoplanin antibody |
|||
| 70R-50819 | Fitzgerald | 100 ul | EUR 292.8 |
|
Description: Purified Polyclonal Podoplanin antibody |
|||
Podoplanin antibody |
|||
| 70R-13952 | Fitzgerald | 100 ug | EUR 366 |
|
Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
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Podoplanin Antibody |
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| 49474-100ul | SAB | 100ul | EUR 399.6 |
Anti-Podoplanin Rabbit Monoclonal Antibody |
- Podoplanin is expressed in a lot of cancers, along with oral cancers and thoughts tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in most cancers metastasis and tumor malignancy. We beforehand established many monoclonal antibodies (mAbs) in the direction of human podoplanin using the cancer-specific mAb (CasMab) experience. LpMab-23 (IgG1, kappa), one in every of many mouse anti-podoplanin mAbs, was confirmed to be a CasMab.
- Nonetheless, we’ve no longer confirmed the usefulness of LpMab-23 for antibody treatment in the direction of podoplanin-expressing cancers. On this analysis, we first determined the minimal epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, notably Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a important epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether or not or not chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor train.
Anti-D2-40 Podoplanin antibody
- In stream cytometry, chLpMab-23 confirmed extreme sensitivity in the direction of a podoplanin-expressing glioblastoma cell line, LN319, and an oral most cancers cell line, HSC-2. chLpMab-23 moreover confirmed ADCC train in the direction of podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft fashions with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor train using human pure killer cells, indicating that chLpMab-23 could very nicely be useful for antibody treatment in the direction of podoplanin-expressing cancers.